In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles

doi:10.1016/j.radphyschem.2017.01.006

	In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles
	Li, Rong 1; Wu, Guozhong1,2 ; Cai, Ximing 1; Ye, Yin 1
	2017-05
发表期刊	RADIATION PHYSICS AND CHEMISTRY
ISSN	0969-806X
卷号	134 页码:27-32
发表状态	已发表
DOI	10.1016/j.radphyschem.2017.01.006
摘要	Poly(acrylic acid), poly(sodium styrenesulfonate), and poly(acrylic acid-co-sodium styrenesulfonate) chains were immobilized onto poly(vinyl alcohol) (PVA) particles via a facile gamma-ray simultaneous irradiation induced graft polymerization technique, which were confirmed by the attenuated total reflection Fourier transform infrared spectroscopy and the high swelling ratios of modified PVA particles. The effects of absorbed dose, dose rate, Cu2+ concentration and monomer concentration on the degree of grafting (DG) of PVA particles were investigated to find out a feasible process for preparing polyanionic chains graft-modified PVA particles. The clotting time results illustrated that both PVA-g-PAA and PVA-g-PSSS particles presented excellent anticoagulant activity, and the activated partial thromboplastin time (APTI), prothrombin time (PT) and thrombin time (TT) were effectively prolonged with the increase of DG(AA) and DG(sss), respectively. Furthermore, the anticoagulant activity of PVA-g-PSSS samples was more efficient than that of PVA-g-PAA samples. However, the anticoagulant effect of PVA-g-P(AA-co-SSS) samples was different from that of PVA-g-PAA and PVA-g-PSSS samples, and was similar to that of heparin, mainly elongating the APTT and TT. This might be due to both of them containing the same negative-charged groups. Additionally, the grafted PVA particles were all non hemolytic, showing good blood compatibility.
关键词	gamma-ray simultaneous irradiation induced graft polymerization Poly(vinyl alcohol) Acrylic acid Sodium styrenesulfonate Anticoagulant activity
收录类别	SCI ; EI
语种	英语
资助项目	National Natural Science Foundation of China[11605275] ; National Natural Science Foundation of China[11675247]
WOS研究方向	Chemistry ; Nuclear Science & Technology ; Physics
WOS类目	Chemistry, Physical ; Nuclear Science & Technology ; Physics, Atomic, Molecular & Chemical
WOS记录号	WOS:000395607900005
出版者	PERGAMON-ELSEVIER SCIENCE LTD
EI入藏号	20170403286452
EI主题词	Ascorbic acid ; Carboxylic acids ; Chains ; Fourier transform infrared spectroscopy ; Gamma rays ; Grafting (chemical) ; Irradiation ; Organic acids ; Polymerization ; Sodium
EI分类号	Alkali Metals:549.1 ; Mechanical Drives:602.1 ; Chemistry:801 ; Chemical Reactions:802.2 ; Organic Compounds:804.1 ; Organic Polymers:815.1.1 ; Polymerization:815.2 ; Atomic and Molecular Physics:931.3
WOS关键词	STYRENE-SULFONATE ; CROSS-LINKING ; HEMOCOMPATIBILITY ; CELLULOSE ; POLYMERS ; HEPARIN ; SURFACE ; BIOCOMPATIBILITY ; SULFATE
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1400
专题	物质科学与技术学院_特聘教授组_吴国忠组
通讯作者	Ye, Yin
作者单位	1.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China 2.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Li, Rong,Wu, Guozhong,Cai, Ximing,et al. In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles[J]. RADIATION PHYSICS AND CHEMISTRY,2017,134:27-32.
APA	Li, Rong,Wu, Guozhong,Cai, Ximing,&Ye, Yin.(2017).In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles.RADIATION PHYSICS AND CHEMISTRY,134,27-32.
MLA	Li, Rong,et al."In vitro anticoagulant activity of polyanionic graft chains modified poly(vinyl alcohol) particles".RADIATION PHYSICS AND CHEMISTRY 134(2017):27-32.