Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening

doi:10.1038/cr.2017.36

	Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening
	Ji, Shuyi 1; Zhu, Linying 1; Gao, Yimeng 1; Zhang, Xiaoran 2; Yan, Yupeng 1; Cen, Jin 1; Li, Rongxia 3; Zeng, Rong 3; Liao, Lujian 4; Hou, Chunhui 5; Gao, Yawei 6; Gao, Shaorong 6; Wei, Gang 2; Hui, Lijian1,7
	2017-05
发表期刊	CELL RESEARCH (IF:28.1[JCR-2023],36.4[5-Year])
ISSN	1001-0602
卷号	27 期号:5 页码:642-656
发表状态	已发表
DOI	10.1038/cr.2017.36
摘要	Lineage conversion by expression of lineage-specific transcription factors is a process of epigenetic remodeling that has low efficiency. The mechanism by which a cell resists lineage conversion is largely unknown. Using hepatic-specific transcription factors Foxa3, Hnf1 alpha and Gata4 (3TF) to induce hepatic conversion in mouse fibroblasts, we showed that 3TF induced strong activation of the ATM-p53 pathway, which led to proliferation arrest and cell death, and it further prevented hepatic conversion. Notably, ATM activation, independent of DNA damage, responded to chromatin opening during hepatic conversion. By characterizing the early molecular events during hepatic conversion, we found that Baf60b, a member of the SWI/SNF chromatin remodeling complex, links chromatin opening to ATM activation by facilitating ATM recruitment to the open chromatin regions of a panel of hepatic gene loci. These findings shed light on cellular responses to lineage conversion by revealing a function of the ATM-p53 pathway in sensing chromatin opening.
关键词	Baf60b ATM p53 chromatin remodeling lineage conversion hepatic conversion
收录类别	SCI
语种	英语
资助项目	Science and Technology Commission of Shanghai Municipality[14XD1404200] ; Science and Technology Commission of Shanghai Municipality[15JC1400200]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000400443300008
出版者	INST BIOCHEMISTRY & CELL BIOLOGY
WOS关键词	DNA-DAMAGE ; DEFINED FACTORS ; CANCER-THERAPY ; SOMATIC-CELLS ; P53 PATHWAY ; IPS CELLS ; FIBROBLASTS ; MECHANISMS ; ATM ; PLURIPOTENCY
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1393
专题	生命科学与技术学院_特聘教授组_惠利健组
通讯作者	Wei, Gang; Hui, Lijian
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China 4.East China Normal Univ, Sch Life Sci, Shanghai Key Lab Regulatory Biol, Shanghai 200241, Peoples R China 5.South Univ Sci & Technol China, Dept Biol, Shenzhen 518055, Guangdong, Peoples R China 6.Tongji Univ, Sch Life Sci & Technol, Shanghai Key Lab Signaling & Dis Res, Clin & Translat Res Ctr,Shanghai Maternity & Infa, Shanghai 200092, Peoples R China 7.Shanghai Tech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Ji, Shuyi,Zhu, Linying,Gao, Yimeng,et al. Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening[J]. CELL RESEARCH,2017,27(5):642-656.
APA	Ji, Shuyi.,Zhu, Linying.,Gao, Yimeng.,Zhang, Xiaoran.,Yan, Yupeng.,...&Hui, Lijian.(2017).Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening.CELL RESEARCH,27(5),642-656.
MLA	Ji, Shuyi,et al."Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening".CELL RESEARCH 27.5(2017):642-656.