Micro-coevolution of host genetics with gut microbiome in three Chinese ethnic groups
2021-11-20
发表期刊JOURNAL OF GENETICS AND GENOMICS (IF:6.6[JCR-2023],5.8[5-Year])
ISSN1673-8527
EISSN1873-5533
卷号48期号:11
发表状态已发表
DOI10.1016/j.jgg.2021.09.002
摘要

Understanding the micro-coevolution of the human gut microbiome with host genetics is challenging but essential in both evolutionary and medical studies. To gain insight into the interactions between host genetic variation and the gut microbiome, we analyzed both the human genome and gut microbiome collected from a cohort of 190 students in the same boarding college and representing 3 ethnic groups, Uyghur, Kazakh, and Han Chinese. We found that differences in gut microbiome were greater between genetically distinct ethnic groups than those genetically closely related ones in taxonomic composition, functional composition, enterotype stratification, and microbiome genetic differentiation. We also observed considerable correlations between host genetic variants and the abundance of a subset of gut microbial species. Notably, interactions between gut microbiome species and host genetic variants might have coordinated effects on specific human phenotypes. Bacteroides ovatus, previously reported to modulate intestinal immunity, is significantly correlated with the host genetic variant rs12899811 (meta-P = 5.55 x 10(-5)), which regulates the VPS33B expression in the colon, acting as a tumor suppressor of colorectal cancer. These results advance our understanding of the micro-coevolution of the human gut microbiome and their interactive effects with host genetic variation on phenotypic diversity. Copyright (C) 2021, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.

关键词Micro-coevolution Gut microbiome Host genetics Uyghur Kazakh Han Chinese
URL查看原文
收录类别SCI ; SCIE
语种英语
资助项目National Natural Science Foundation of China (NSFC)[31771388,32030020,31525014,32071465,31871334,31671374,91731303,31961130380,32041008] ; Chinese Academy of Sciences[
WOS研究方向Biochemistry & Molecular Biology ; Genetics & Heredity
WOS类目Biochemistry & Molecular Biology ; Genetics & Heredity
WOS记录号WOS:000721640600003
出版者SCIENCE PRESS
引用统计
正在获取...
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/138717
专题生命科学与技术学院
生命科学与技术学院_特聘教授组_徐书华组
通讯作者Ning, Kang; Xu, Shuhua
作者单位
1.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Dept Bioinformat & Syst Biol,Minist Educ,Key Lab, Ctr AI Biol,Hubei Key Lab Bioinformat & Mol Imagi, Wuhan 430074, Peoples R China
2.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Key Lab Computat Biol, Shanghai 200031, Peoples R China
3.Fudan Univ, Ctr Evolutionary Biol, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci,State Key Lab Genet Engn, Shanghai 200438, Peoples R China
4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
5.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China
6.Zhengzhou Univ, Henan Inst Med & Pharmaceut Sci, Zhengzhou 450052, Peoples R China
7.Fudan Univ, Human Phenome Inst, Shanghai 201203, Peoples R China
通讯作者单位生命科学与技术学院
推荐引用方式
GB/T 7714
Cheng, Mingyue,Ge, Xueling,Zhong, Chaofang,et al. Micro-coevolution of host genetics with gut microbiome in three Chinese ethnic groups[J]. JOURNAL OF GENETICS AND GENOMICS,2021,48(11).
APA Cheng, Mingyue,Ge, Xueling,Zhong, Chaofang,Fu, Ruiqing,Ning, Kang,&Xu, Shuhua.(2021).Micro-coevolution of host genetics with gut microbiome in three Chinese ethnic groups.JOURNAL OF GENETICS AND GENOMICS,48(11).
MLA Cheng, Mingyue,et al."Micro-coevolution of host genetics with gut microbiome in three Chinese ethnic groups".JOURNAL OF GENETICS AND GENOMICS 48.11(2021).
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
个性服务
查看访问统计
谷歌学术
谷歌学术中相似的文章
[Cheng, Mingyue]的文章
[Ge, Xueling]的文章
[Zhong, Chaofang]的文章
百度学术
百度学术中相似的文章
[Cheng, Mingyue]的文章
[Ge, Xueling]的文章
[Zhong, Chaofang]的文章
必应学术
必应学术中相似的文章
[Cheng, Mingyue]的文章
[Ge, Xueling]的文章
[Zhong, Chaofang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。