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Micro-coevolution of host genetics with gut microbiome in three Chinese ethnic groups | |
2021-11-20 | |
发表期刊 | JOURNAL OF GENETICS AND GENOMICS (IF:6.6[JCR-2023],5.8[5-Year]) |
ISSN | 1673-8527 |
EISSN | 1873-5533 |
卷号 | 48期号:11 |
发表状态 | 已发表 |
DOI | 10.1016/j.jgg.2021.09.002 |
摘要 | Understanding the micro-coevolution of the human gut microbiome with host genetics is challenging but essential in both evolutionary and medical studies. To gain insight into the interactions between host genetic variation and the gut microbiome, we analyzed both the human genome and gut microbiome collected from a cohort of 190 students in the same boarding college and representing 3 ethnic groups, Uyghur, Kazakh, and Han Chinese. We found that differences in gut microbiome were greater between genetically distinct ethnic groups than those genetically closely related ones in taxonomic composition, functional composition, enterotype stratification, and microbiome genetic differentiation. We also observed considerable correlations between host genetic variants and the abundance of a subset of gut microbial species. Notably, interactions between gut microbiome species and host genetic variants might have coordinated effects on specific human phenotypes. Bacteroides ovatus, previously reported to modulate intestinal immunity, is significantly correlated with the host genetic variant rs12899811 (meta-P = 5.55 x 10(-5)), which regulates the VPS33B expression in the colon, acting as a tumor suppressor of colorectal cancer. These results advance our understanding of the micro-coevolution of the human gut microbiome and their interactive effects with host genetic variation on phenotypic diversity. Copyright (C) 2021, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved. |
关键词 | Micro-coevolution Gut microbiome Host genetics Uyghur Kazakh Han Chinese |
URL | 查看原文 |
收录类别 | SCI ; SCIE |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China (NSFC)[31771388,32030020,31525014,32071465,31871334,31671374,91731303,31961130380,32041008] ; Chinese Academy of Sciences[ |
WOS研究方向 | Biochemistry & Molecular Biology ; Genetics & Heredity |
WOS类目 | Biochemistry & Molecular Biology ; Genetics & Heredity |
WOS记录号 | WOS:000721640600003 |
出版者 | SCIENCE PRESS |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/138717 |
专题 | 生命科学与技术学院 生命科学与技术学院_特聘教授组_徐书华组 |
通讯作者 | Ning, Kang; Xu, Shuhua |
作者单位 | 1.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Dept Bioinformat & Syst Biol,Minist Educ,Key Lab, Ctr AI Biol,Hubei Key Lab Bioinformat & Mol Imagi, Wuhan 430074, Peoples R China 2.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Key Lab Computat Biol, Shanghai 200031, Peoples R China 3.Fudan Univ, Ctr Evolutionary Biol, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci,State Key Lab Genet Engn, Shanghai 200438, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 5.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China 6.Zhengzhou Univ, Henan Inst Med & Pharmaceut Sci, Zhengzhou 450052, Peoples R China 7.Fudan Univ, Human Phenome Inst, Shanghai 201203, Peoples R China |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Cheng, Mingyue,Ge, Xueling,Zhong, Chaofang,et al. Micro-coevolution of host genetics with gut microbiome in three Chinese ethnic groups[J]. JOURNAL OF GENETICS AND GENOMICS,2021,48(11). |
APA | Cheng, Mingyue,Ge, Xueling,Zhong, Chaofang,Fu, Ruiqing,Ning, Kang,&Xu, Shuhua.(2021).Micro-coevolution of host genetics with gut microbiome in three Chinese ethnic groups.JOURNAL OF GENETICS AND GENOMICS,48(11). |
MLA | Cheng, Mingyue,et al."Micro-coevolution of host genetics with gut microbiome in three Chinese ethnic groups".JOURNAL OF GENETICS AND GENOMICS 48.11(2021). |
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