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| Tankyrase-1-mediated degradation of Golgin45 regulates glycosyltransferase trafficking and protein glycosylation in Rab2-GTP-dependent manner | |
| 2021-12-07 | |
| Source Publication | COMMUNICATIONS BIOLOGY
 |
| EISSN | 2399-3642 |
| Volume | 4Issue:1 |
| Status | 已发表 |
| DOI | 10.1038/s42003-021-02899-0 |
| Abstract | ["Xihua Yue et al. report that Tankyrase-1 controls poly-ADP-ribosylation of Golgin45, a Golgi structural protein, which has a profound influence on glycosyltransferase trafficking and protein glycosylation at the Golgi. This may shed new light onto mechanisms involved in development and oncogenic transformation.","Altered glycosylation plays an important role during development and is also a hallmark of increased tumorigenicity and metastatic potentials of several cancers. We report here that Tankyrase-1 (TNKS1) controls protein glycosylation by Poly-ADP-ribosylation (PARylation) of a Golgi structural protein, Golgin45, at the Golgi. TNKS1 is a Golgi-localized peripheral membrane protein that plays various roles throughout the cell, ranging from telomere maintenance to Glut4 trafficking. Our study indicates that TNKS1 localization to the Golgi apparatus is mediated by Golgin45. TNKS1-dependent control of Golgin45 protein stability influences protein glycosylation, as shown by Glycomic analysis. Further, FRAP experiments indicated that Golgin45 protein level modulates Golgi glycosyltransferease trafficking in Rab2-GTP-dependent manner. Taken together, these results suggest that TNKS1-dependent regulation of Golgin45 may provide a molecular underpinning for altered glycosylation at the Golgi during development or oncogenic transformation."] |
| URL | 查看原文 |
| Indexed By | SCI ; SCIE |
| Language | 英语 |
| Funding Project | Shanghai Pujiang Program[16PJ1407] ; National Research Foundation of Korea (NRF) - Korea government (MSIT, Ministry of Science and ICT)[2018R1A2B6008287] |
| WOS Research Area | Life Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics |
| WOS Subject | Biology ; Multidisciplinary Sciences |
| WOS ID | WOS:000727869000005 |
| Publisher | NATURE PORTFOLIO |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/138698 |
| Collection | 生命科学与技术学院_特聘教授组_James E. Rothman组 物质科学与技术学院_PI研究组_yongjin lee组 生命科学与技术学院_硕士生 生命科学与技术学院_博士生 |
| Corresponding Author | Lee, Intaek |
| Affiliation | 1.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 2.Yale Univ, Dept Cell Biol, Sch Med, New Haven, CT 06520 USA 3.Changwon Natl Univ, Dept Chem, Chang Won, Gyeongnam, South Korea 4.Shanghai Tech Univ, Sch Phys Sci & Technol, Shanghai, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China |
| First Author Affilication | School of Life Science and Technology |
| Corresponding Author Affilication | School of Life Science and Technology |
| First Signature Affilication | School of Life Science and Technology |
| Recommended Citation GB/T 7714 | Yue, Xihua,Tiwari, Neeraj,Zhu, Lianhui,et al. Tankyrase-1-mediated degradation of Golgin45 regulates glycosyltransferase trafficking and protein glycosylation in Rab2-GTP-dependent manner[J]. COMMUNICATIONS BIOLOGY,2021,4(1). |
| APA | Yue, Xihua.,Tiwari, Neeraj.,Zhu, Lianhui.,Ngo, Hai Dang Truong.,Lim, Jae-Min.,...&Lee, Intaek.(2021).Tankyrase-1-mediated degradation of Golgin45 regulates glycosyltransferase trafficking and protein glycosylation in Rab2-GTP-dependent manner.COMMUNICATIONS BIOLOGY,4(1). |
| MLA | Yue, Xihua,et al."Tankyrase-1-mediated degradation of Golgin45 regulates glycosyltransferase trafficking and protein glycosylation in Rab2-GTP-dependent manner".COMMUNICATIONS BIOLOGY 4.1(2021). |
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