Cytotoxic germacrane-type sesquiterpene lactones from the whole plant of Inula cappa

doi:10.1016/j.cclet.2016.11.011

	Cytotoxic germacrane-type sesquiterpene lactones from the whole plant of Inula cappa
	Wu, Jie-Wei 1,2,3; Tang, Chun-Ping 1,2; Cai, Yao-Yao 4; Ke, Chang-Qiang 1,2; Lin, Li-Gen 5; Yao, Sheng 1,2; Ye, Yang1,2,6
	2017-05
发表期刊	CHINESE CHEMICAL LETTERS (IF:9.4[JCR-2023],7.3[5-Year])
ISSN	1001-8417
卷号	28 期号:5 页码:927-930
发表状态	已发表
DOI	10.1016/j.cclet.2016.11.011
摘要	Phytochemical investigation on the whole plant of Inula cappa led to the isolation of two new germacrane-type sesquiterpene lactones, ineupatolides D and E (1 and 2), together with three known analogs. The structures of the new compounds were established by extensive analysis of 1D and 2D NMR spectra, as well as MS data. Their absolute configurations were determined by CD spectra. All compounds showed moderate inhibitory effects on A431, A549, BGC-823, HL-60, HT-29, and MCF-7 cancer cell lines with IC50 values ranging from 2.1 to 36.3 mu M. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
关键词	Inula cappa Germacrane Sesquiterpene lactones Ineupatolide D Ineupatolide E
收录类别	SCI
语种	英语
资助项目	University of Macau[MYRG2014-00020-ICMS-QRCM] ; University of Macau[MYRG2015-00153-ICMS-QRCM]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000402444600001
出版者	ELSEVIER SCIENCE INC
WOS关键词	PHENOLIC GLYCOSIDES
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1382
专题	生命科学与技术学院_特聘教授组_叶阳组
通讯作者	Yao, Sheng; Ye, Yang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Dept NMR Technol Serv, Publ Tech Serv Ctr, Shanghai 201203, Peoples R China 5.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Wu, Jie-Wei,Tang, Chun-Ping,Cai, Yao-Yao,et al. Cytotoxic germacrane-type sesquiterpene lactones from the whole plant of Inula cappa[J]. CHINESE CHEMICAL LETTERS,2017,28(5):927-930.
APA	Wu, Jie-Wei.,Tang, Chun-Ping.,Cai, Yao-Yao.,Ke, Chang-Qiang.,Lin, Li-Gen.,...&Ye, Yang.(2017).Cytotoxic germacrane-type sesquiterpene lactones from the whole plant of Inula cappa.CHINESE CHEMICAL LETTERS,28(5),927-930.
MLA	Wu, Jie-Wei,et al."Cytotoxic germacrane-type sesquiterpene lactones from the whole plant of Inula cappa".CHINESE CHEMICAL LETTERS 28.5(2017):927-930.