Response Patterns of GABAergic Neurons in the Anterior Piriform Cortex of Awake Mice

doi:10.1093/cercor/bhw175

	Response Patterns of GABAergic Neurons in the Anterior Piriform Cortex of Awake Mice
	Hu, Rongfeng 1,2; Zhang, Juen 3; Luo, Minmin 3; Hu, Ji2
	2017-06
发表期刊	CEREBRAL CORTEX (IF:2.9[JCR-2023],3.7[5-Year])
ISSN	1047-3211
卷号	27 期号:6 页码:3110-3124
发表状态	已发表
DOI	10.1093/cercor/bhw175
摘要	Local inhibition by gamma-amino butyric acid (GABA)-containing neurons is of vital importance for the operation of sensory cortices. However, the physiological response patterns of cortical GABAergic neurons are poorly understood, especially in the awake condition. Here, we utilized the recently developed optical tagging technique to specifically record GABAergic neurons in the anterior piriform cortex (aPC) in awake mice. The identified aPC GABAergic neurons were stimulated with robotic delivery of 32 distinct odorants, which covered a broad range of functional groups. We found that aPC GABAergic neurons could be divided into 4 types based on their response patterns. Type I, type II, and type III neurons displayed broad excitatory responses to test odorants with different dynamics. Type I neurons were constantly activated during odorant stimulation, whereas type II neurons were only transiently activated at the onset of odorant delivery. In addition, type III neurons displayed transient excitatory responses both at the onset and termination of odorant presentation. Interestingly, type IV neurons were broadly inhibited by most of the odorants. Taken together, aPC GABAergic neurons adopt different strategies to affect the cortical circuitry. Our results will allow for better understanding of the role of cortical GABAergic interneurons in sensory information processing.
关键词	cortical circuitry head-fixed multichannel recording optical tagging sensory processing
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[91432113]
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000402824700002
出版者	OXFORD UNIV PRESS INC
WOS关键词	MOUSE OLFACTORY-BULB ; ODOR REPRESENTATIONS ; INHIBITORY INTERNEURONS ; AUDITORY-CORTEX ; REWARD SIGNALS ; CIRCUITS ; RECEPTOR ; INPUT ; RAT ; ACTIVATION
原始文献类型	Article
通讯作者	Hu, Ji
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1358
专题	生命科学与技术学院_PI研究组_胡霁组
通讯作者	Hu, Ji
作者单位	1.Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Ctr Neuron & Dis, Xian 710054, Shaanxi, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Natl Inst Biol Sci, Beijing 102206, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Hu, Rongfeng,Zhang, Juen,Luo, Minmin,et al. Response Patterns of GABAergic Neurons in the Anterior Piriform Cortex of Awake Mice[J]. CEREBRAL CORTEX,2017,27(6):3110-3124.
APA	Hu, Rongfeng,Zhang, Juen,Luo, Minmin,&Hu, Ji.(2017).Response Patterns of GABAergic Neurons in the Anterior Piriform Cortex of Awake Mice.CEREBRAL CORTEX,27(6),3110-3124.
MLA	Hu, Rongfeng,et al."Response Patterns of GABAergic Neurons in the Anterior Piriform Cortex of Awake Mice".CEREBRAL CORTEX 27.6(2017):3110-3124.