Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency

doi:10.3390/nano11112939

KMS > 物质科学与技术学院 > PI研究组 > Osamu Terasaki组

	Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency
	Goncalves, Joana 1; Nunes, Claudia 1; Ferreira, Liliana 2,3; Cruz, Maria Margarida 3; Oliveira, Helena 4; Bastos, Veronica 4; Mayoral, Alvaro5,6,7 ; Zhang, Qing ; Ferreira, Paula 1
	2021-11
发表期刊	NANOMATERIALS
EISSN	2079-4991
卷号	11 期号:11
DOI	10.3390/nano11112939
摘要	Magnetic nanoparticles (NP), such as magnetite, have been the subject of research for application in the biomedical field, especially in Magnetic Hyperthermia Therapy (MHT), a promising technique for cancer therapy. NP are often coated with different compounds such as natural or synthetic polymers to protect them from oxidation and enhance their colloidal electrostatic stability while maintaining their thermal efficiency. In this work, the synthesis and characterization of magnetite nanoparticles coated with fucoidan, a biopolymer with recognized biocompatibility and antitumoral activity, is reported. The potential application of NP in MHT was evaluated through the assessment of Specific Loss Power (SLP) under an electromagnetic field amplitude of 14.7 kA m(-1) and at 276 kHz. For fucoidan-coated NP, it was obtained SLP values of 100 and 156 W/g, corresponding to an Intrinsic Loss Power (ILP) of 1.7 and 2.6 nHm(2)kg(-1), respectively. These values are, in general, higher than the ones reported in the literature for non-coated magnetite NP or coated with other polymers. Furthermore, in vitro assays showed that fucoidan and fucoidan-coated NP are biocompatible. The particle size (between ca. 6 to 12 nm), heating efficiency, and biocompatibility of fucoidan-coated magnetite NP meet the required criteria for MHT application.
关键词	magnetic nanoparticles magnetite fucoidan magnetic hyperthermia therapy biocompatibility
URL	查看原文
收录类别	SCIE
语种	英语
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号	WOS:000725148600001
出版者	MDPI
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/134176
专题	物质科学与技术学院_PI研究组_Osamu Terasaki组
通讯作者	Nunes, Claudia; Ferreira, Paula
作者单位	1.Univ Aveiro, CICECO Aveiro Inst Mat, Dept Mat & Ceram Engn, P-3810193 Aveiro, Portugal; 2.Univ Coimbra, Dept Phys, P-3004516 Coimbra, Portugal; 3.Univ Lisbon, Fac Ciencias, Biosyst & Integrat Sci Inst BioISI, P-1749016 Lisbon, Portugal; 4.Univ Aveiro, CESAM, Dept Biol, P-3810193 Aveiro, Portugal; 5.Univ Zaragoza 12, Inst Nanociencia Mat Aragon INMA, Spanish Natl Res Council CSIC, Calle Pedro Cerbuna, Zaragoza 50009, Spain; 6.Univ Zaragoza, Adv Microscopy Lab LMA, Zaragoza 50018, Spain; 7.ShanghaiTech Univ, Sch Phys Sci & Technol SPST, Ctr Highresolut Elect Microscopy CeEM, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Goncalves, Joana,Nunes, Claudia,Ferreira, Liliana,et al. Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency[J]. NANOMATERIALS,2021,11(11).
APA	Goncalves, Joana.,Nunes, Claudia.,Ferreira, Liliana.,Cruz, Maria Margarida.,Oliveira, Helena.,...&Ferreira, Paula.(2021).Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency.NANOMATERIALS,11(11).
MLA	Goncalves, Joana,et al."Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency".NANOMATERIALS 11.11(2021).