NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes
Zhou, Zhi1,2; Kawabe, Hiroshi3; Suzuki, Atsushi4; Shinmyozu, Kaori5; Saga, Yumiko1,6,7
2017-06-06
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
卷号8
发表状态已发表
DOI10.1038/ncomms15662
摘要P bodies (PBs) and stress granules (SGs) are conserved cytoplasmic aggregates of cellular messenger ribonucleoprotein complexes (mRNPs) that are implicated in mRNA metabolism and play crucial roles in adult stem cell homeostasis and stress responses. However, the mechanisms underlying the dynamics of mRNP granules are poorly understood. Here, we report NEDD4, an E3 ubiquitin ligase, as a key regulator of mRNP dynamics that controls the size of the spermatogonial progenitor cell (SPC) pool. We find that NEDD4 targets an RNA-binding protein, NANOS2, in spermatogonia to destabilize it, leading to cell differentiation. In addition, NEDD4 is required for SG clearance. NEDD4 targets SGs and facilitates their rapid clearance through the endosomal-lysosomal pathway during the recovery period. Therefore, NEDD4 controls the turnover of mRNP components and inhibits pathological SG accumulation. Accordingly, we propose that a NEDD4-mediated mechanism regulates mRNP dynamics, and facilitates SPC homeostasis and viability under normal and stress conditions.
收录类别SCI
语种英语
资助项目Ministry of Education, Culture, Sports, Science and Technology[25112002]
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000402752600001
出版者NATURE PUBLISHING GROUP
WOS关键词UBIQUITIN LIGASE NEDD4-1 ; BINDING PROTEIN NANOS2 ; SELF-RENEWAL ; MOUSE SPERMATOGENESIS ; HEAT-STRESS ; GRANULES ; PATHWAY ; DIFFERENTIATION ; DEGRADATION ; MAINTENANCE
原始文献类型Article
通讯作者Saga, Yumiko
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1339
专题生命科学与技术学院_PI研究组_周智组
通讯作者Saga, Yumiko
作者单位1.Natl Inst Genet, Div Mammalian Dev, Genet Strains Res Ctr, Yata 1111, Mishima, Shizuoka 4118540, Japan
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
3.Max Planck Inst Expt Med, Dept Mol Neurobiol, Hermann Rein Str 3D, D-37075 Gottingen, Germany
4.Yokohama Natl Univ, Div Mat Sci & Chem Engn, Fac Engn, Yokohama, Kanagawa 2408501, Japan
5.Natl Cerebral & Cardiovasc Ctr, 5-7-1 Fujishiro Dai, Suita, Osaka, Japan
6.SOKENDAI, Dept Genet, Yata 1111, Mishima, Shizuoka 4118540, Japan
7.Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan
第一作者单位生命科学与技术学院
推荐引用方式
GB/T 7714
Zhou, Zhi,Kawabe, Hiroshi,Suzuki, Atsushi,et al. NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes[J]. NATURE COMMUNICATIONS,2017,8.
APA Zhou, Zhi,Kawabe, Hiroshi,Suzuki, Atsushi,Shinmyozu, Kaori,&Saga, Yumiko.(2017).NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes.NATURE COMMUNICATIONS,8.
MLA Zhou, Zhi,et al."NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes".NATURE COMMUNICATIONS 8(2017).
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