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NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes | |
Zhou, Zhi1,2; Kawabe, Hiroshi3; Suzuki, Atsushi4; Shinmyozu, Kaori5; Saga, Yumiko1,6,7 | |
2017-06-06 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
卷号 | 8 |
发表状态 | 已发表 |
DOI | 10.1038/ncomms15662 |
摘要 | P bodies (PBs) and stress granules (SGs) are conserved cytoplasmic aggregates of cellular messenger ribonucleoprotein complexes (mRNPs) that are implicated in mRNA metabolism and play crucial roles in adult stem cell homeostasis and stress responses. However, the mechanisms underlying the dynamics of mRNP granules are poorly understood. Here, we report NEDD4, an E3 ubiquitin ligase, as a key regulator of mRNP dynamics that controls the size of the spermatogonial progenitor cell (SPC) pool. We find that NEDD4 targets an RNA-binding protein, NANOS2, in spermatogonia to destabilize it, leading to cell differentiation. In addition, NEDD4 is required for SG clearance. NEDD4 targets SGs and facilitates their rapid clearance through the endosomal-lysosomal pathway during the recovery period. Therefore, NEDD4 controls the turnover of mRNP components and inhibits pathological SG accumulation. Accordingly, we propose that a NEDD4-mediated mechanism regulates mRNP dynamics, and facilitates SPC homeostasis and viability under normal and stress conditions. |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Ministry of Education, Culture, Sports, Science and Technology[25112002] |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000402752600001 |
出版者 | NATURE PUBLISHING GROUP |
WOS关键词 | UBIQUITIN LIGASE NEDD4-1 ; BINDING PROTEIN NANOS2 ; SELF-RENEWAL ; MOUSE SPERMATOGENESIS ; HEAT-STRESS ; GRANULES ; PATHWAY ; DIFFERENTIATION ; DEGRADATION ; MAINTENANCE |
原始文献类型 | Article |
通讯作者 | Saga, Yumiko |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1339 |
专题 | 生命科学与技术学院_PI研究组_周智组 |
通讯作者 | Saga, Yumiko |
作者单位 | 1.Natl Inst Genet, Div Mammalian Dev, Genet Strains Res Ctr, Yata 1111, Mishima, Shizuoka 4118540, Japan 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Max Planck Inst Expt Med, Dept Mol Neurobiol, Hermann Rein Str 3D, D-37075 Gottingen, Germany 4.Yokohama Natl Univ, Div Mat Sci & Chem Engn, Fac Engn, Yokohama, Kanagawa 2408501, Japan 5.Natl Cerebral & Cardiovasc Ctr, 5-7-1 Fujishiro Dai, Suita, Osaka, Japan 6.SOKENDAI, Dept Genet, Yata 1111, Mishima, Shizuoka 4118540, Japan 7.Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan |
第一作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Zhou, Zhi,Kawabe, Hiroshi,Suzuki, Atsushi,et al. NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Zhou, Zhi,Kawabe, Hiroshi,Suzuki, Atsushi,Shinmyozu, Kaori,&Saga, Yumiko.(2017).NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes.NATURE COMMUNICATIONS,8. |
MLA | Zhou, Zhi,et al."NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes".NATURE COMMUNICATIONS 8(2017). |
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