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A dual role of human tRNA methyltransferase hTrmt13 in regulating translation and transcription
2022-03-15
发表期刊EMBO JOURNAL (IF:9.4[JCR-2023],11.0[5-Year])
ISSN0261-4189
EISSN1460-2075
发表状态已发表
DOI10.15252/embj.2021108544
摘要

Since numerous RNAs and RBPs prevalently localize to active chromatin regions, many RNA-binding proteins (RBPs) may be potential transcriptional regulators. RBPs are generally thought to regulate transcription via noncoding RNAs. Here, we describe a distinct, dual mechanism of transcriptional regulation by the previously uncharacterized tRNA-modifying enzyme, hTrmt13. On one hand, hTrmt13 acts in the cytoplasm to catalyze 2'-O-methylation of tRNAs, thus regulating translation in a manner depending on its tRNA-modification activity. On the other hand, nucleus-localized hTrmt13 directly binds DNA as a transcriptional co-activator of key epithelial-mesenchymal transition factors, thereby promoting cell migration independent of tRNA-modification activity. These dual functions of hTrmt13 are mutually exclusive, as it can bind either DNA or tRNA through its CHHC zinc finger domain. Finally, we find that hTrmt13 expression is tightly associated with poor prognosis and survival in diverse cancer patients. Our discovery of the noncatalytic roles of an RNA-modifying enzyme provides a new perspective for understanding epitranscriptomic regulation.

关键词cancer metastasis RNA modification transcription translation tRNA
学科门类理学
收录类别SCI ; SCIE
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
WOS类目Biochemistry & Molecular Biology ; Cell Biology
WOS记录号WOS:000724073900001
出版者WILEY
原始文献类型Article
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文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/133103
专题生命科学与技术学院_PI研究组_刘如娟组
生命科学与技术学院_特聘教授组_王恩多组
生命科学与技术学院_博士生
共同第一作者Han Dong; Beisi Xu
通讯作者En-Duo Wang; Ru-Juan Liu
作者单位
1.School of Life Science and Technology, ShanghaiTech University
2.State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China
3.Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA
第一作者单位生命科学与技术学院
通讯作者单位生命科学与技术学院
第一作者的第一单位生命科学与技术学院
推荐引用方式
GB/T 7714
Hao Li,Han Dong,Beisi Xu,et al. A dual role of human tRNA methyltransferase hTrmt13 in regulating translation and transcription[J]. EMBO JOURNAL,2022.
APA Hao Li.,Han Dong.,Beisi Xu.,Qing-Ping Xiong.,Cai-Tao Li.,...&Ru-Juan Liu.(2022).A dual role of human tRNA methyltransferase hTrmt13 in regulating translation and transcription.EMBO JOURNAL.
MLA Hao Li,et al."A dual role of human tRNA methyltransferase hTrmt13 in regulating translation and transcription".EMBO JOURNAL (2022).
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