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A dual role of human tRNA methyltransferase hTrmt13 in regulating translation and transcription | |
2022-03-15 | |
发表期刊 | EMBO JOURNAL (IF:9.4[JCR-2023],11.0[5-Year]) |
ISSN | 0261-4189 |
EISSN | 1460-2075 |
发表状态 | 已发表 |
DOI | 10.15252/embj.2021108544 |
摘要 | Since numerous RNAs and RBPs prevalently localize to active chromatin regions, many RNA-binding proteins (RBPs) may be potential transcriptional regulators. RBPs are generally thought to regulate transcription via noncoding RNAs. Here, we describe a distinct, dual mechanism of transcriptional regulation by the previously uncharacterized tRNA-modifying enzyme, hTrmt13. On one hand, hTrmt13 acts in the cytoplasm to catalyze 2'-O-methylation of tRNAs, thus regulating translation in a manner depending on its tRNA-modification activity. On the other hand, nucleus-localized hTrmt13 directly binds DNA as a transcriptional co-activator of key epithelial-mesenchymal transition factors, thereby promoting cell migration independent of tRNA-modification activity. These dual functions of hTrmt13 are mutually exclusive, as it can bind either DNA or tRNA through its CHHC zinc finger domain. Finally, we find that hTrmt13 expression is tightly associated with poor prognosis and survival in diverse cancer patients. Our discovery of the noncatalytic roles of an RNA-modifying enzyme provides a new perspective for understanding epitranscriptomic regulation. |
关键词 | cancer metastasis RNA modification transcription translation tRNA |
学科门类 | 理学 |
收录类别 | SCI ; SCIE |
语种 | 英语 |
WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
WOS类目 | Biochemistry & Molecular Biology ; Cell Biology |
WOS记录号 | WOS:000724073900001 |
出版者 | WILEY |
原始文献类型 | Article |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/133103 |
专题 | 生命科学与技术学院_PI研究组_刘如娟组 生命科学与技术学院_特聘教授组_王恩多组 生命科学与技术学院_博士生 |
共同第一作者 | Han Dong; Beisi Xu |
通讯作者 | En-Duo Wang; Ru-Juan Liu |
作者单位 | 1.School of Life Science and Technology, ShanghaiTech University 2.State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China 3.Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA |
第一作者单位 | 生命科学与技术学院 |
通讯作者单位 | 生命科学与技术学院 |
第一作者的第一单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Hao Li,Han Dong,Beisi Xu,et al. A dual role of human tRNA methyltransferase hTrmt13 in regulating translation and transcription[J]. EMBO JOURNAL,2022. |
APA | Hao Li.,Han Dong.,Beisi Xu.,Qing-Ping Xiong.,Cai-Tao Li.,...&Ru-Juan Liu.(2022).A dual role of human tRNA methyltransferase hTrmt13 in regulating translation and transcription.EMBO JOURNAL. |
MLA | Hao Li,et al."A dual role of human tRNA methyltransferase hTrmt13 in regulating translation and transcription".EMBO JOURNAL (2022). |
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