Cell proliferation fate mapping reveals regional cardiomyocyte cell-cycle activity in subendocardial muscle of left ventricle
Liu, Xiuxiu1; Pu, Wenjuan1; He, Lingjuan1; Li, Yan1; Zhao, Huan1; Li, Yi1; Liu, Kuo1,2,3; Huang, Xiuzhen1; Weng, Wendong1; Wang, Qing-Dong4; Shen, Linghong5; Zhong, Tao6; Sun, Kun7; Ardehali, Reza8; He, Ben5; Zhou, Bin1,2,3
2021
Source PublicationNATURE COMMUNICATIONS
EISSN2041-1723
Volume12Issue:1
DOI10.1038/s41467-021-25933-5
AbstractCardiac regeneration involves the generation of new cardiomyocytes from cycling cardiomyocytes. Understanding cell-cycle activity of pre-existing cardiomyocytes provides valuable information to heart repair and regeneration. However, the anatomical locations and in situ dynamics of cycling cardiomyocytes remain unclear. Here we develop a genetic approach for a temporally seamless recording of cardiomyocyte-specific cell-cycle activity in vivo. We find that the majority of cycling cardiomyocytes are positioned in the subendocardial muscle of the left ventricle, especially in the papillary muscles. Clonal analysis revealed that a subset of cycling cardiomyocytes have undergone cell division. Myocardial infarction and cardiac pressure overload induce regional patterns of cycling cardiomyocytes. Mechanistically, cardiomyocyte cell cycle activity requires the Hippo pathway effector YAP. These genetic fate-mapping studies advance our basic understanding of cardiomyocyte cell cycle activity and generation in cardiac homeostasis, repair, and regeneration. The adult mammalian heart exhibits stubbornly low levels of cardiomyocyte proliferation, leading to high morbidity after injury or heart attack. Here the authors develop an approach for tracking cardiomyocyte cell cycling and show that the majority are located adjacent to the endocardium.
URL查看原文
Indexed BySCIE
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000702753200021
PublisherNATURE PORTFOLIO
Original Document TypeArticle
Citation statistics
Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/128419
Collection信息科学与技术学院_硕士生
生命科学与技术学院_特聘教授组_周斌组
生命科学与技术学院_硕士生
Affiliation1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci,State Key Lab Cell Bi, Shanghai 200031, Peoples R China;
2.Univ Chinese Acad Sci, Sch Life Sci, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China;
3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China;
4.AstraZeneca, BioPharmaceut R&D, Biosci Cardiovasc Res & Early Dev Cardiovasc Rena, Gothenburg, Sweden;
5.Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Cardiol, Shanghai, Peoples R China;
6.East China Normal Univ, Sch Life Sci, Shanghai, Peoples R China;
7.Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Pediat Cardiol, Shanghai 200092, Peoples R China;
8.UCLA, David Geffen Sch Med, Cardiol, 675 Charles E Young South, Los Angeles, CA 90095 USA
Recommended Citation
GB/T 7714
Liu, Xiuxiu,Pu, Wenjuan,He, Lingjuan,et al. Cell proliferation fate mapping reveals regional cardiomyocyte cell-cycle activity in subendocardial muscle of left ventricle[J]. NATURE COMMUNICATIONS,2021,12(1).
APA Liu, Xiuxiu.,Pu, Wenjuan.,He, Lingjuan.,Li, Yan.,Zhao, Huan.,...&Zhou, Bin.(2021).Cell proliferation fate mapping reveals regional cardiomyocyte cell-cycle activity in subendocardial muscle of left ventricle.NATURE COMMUNICATIONS,12(1).
MLA Liu, Xiuxiu,et al."Cell proliferation fate mapping reveals regional cardiomyocyte cell-cycle activity in subendocardial muscle of left ventricle".NATURE COMMUNICATIONS 12.1(2021).
Files in This Item: Download All
File Name/Size DocType Version Access License
10.1038@s41467-021-2(20166KB)期刊论文出版稿开放获取CC BYView Download
Related Services
Usage statistics
Scholar Google
Similar articles in Scholar Google
[Liu, Xiuxiu]'s Articles
[Pu, Wenjuan]'s Articles
[He, Lingjuan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Liu, Xiuxiu]'s Articles
[Pu, Wenjuan]'s Articles
[He, Lingjuan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Liu, Xiuxiu]'s Articles
[Pu, Wenjuan]'s Articles
[He, Lingjuan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 10.1038@s41467-021-25933-5.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.