Cell proliferation fate mapping reveals regional cardiomyocyte cell-cycle activity in subendocardial muscle of left ventricle
Liu, Xiuxiu1; Pu, Wenjuan1; He, Lingjuan1; Li, Yan1; Zhao, Huan1; Li, Yi1; Liu, Kuo1,2,3; Huang, Xiuzhen1; Weng, Wendong1; Wang, Qing-Dong4
2021
发表期刊NATURE COMMUNICATIONS
EISSN2041-1723
卷号12期号:1
DOI10.1038/s41467-021-25933-5
摘要Cardiac regeneration involves the generation of new cardiomyocytes from cycling cardiomyocytes. Understanding cell-cycle activity of pre-existing cardiomyocytes provides valuable information to heart repair and regeneration. However, the anatomical locations and in situ dynamics of cycling cardiomyocytes remain unclear. Here we develop a genetic approach for a temporally seamless recording of cardiomyocyte-specific cell-cycle activity in vivo. We find that the majority of cycling cardiomyocytes are positioned in the subendocardial muscle of the left ventricle, especially in the papillary muscles. Clonal analysis revealed that a subset of cycling cardiomyocytes have undergone cell division. Myocardial infarction and cardiac pressure overload induce regional patterns of cycling cardiomyocytes. Mechanistically, cardiomyocyte cell cycle activity requires the Hippo pathway effector YAP. These genetic fate-mapping studies advance our basic understanding of cardiomyocyte cell cycle activity and generation in cardiac homeostasis, repair, and regeneration. The adult mammalian heart exhibits stubbornly low levels of cardiomyocyte proliferation, leading to high morbidity after injury or heart attack. Here the authors develop an approach for tracking cardiomyocyte cell cycling and show that the majority are located adjacent to the endocardium.
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收录类别SCIE
语种英语
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000702753200021
出版者NATURE PORTFOLIO
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/128419
专题生命科学与技术学院_硕士生
生命科学与技术学院_特聘教授组_周斌组
通讯作者He, Ben; Zhou, Bin
作者单位1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci,State Key Lab Cell Bi, Shanghai 200031, Peoples R China;
2.Univ Chinese Acad Sci, Sch Life Sci, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China;
3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China;
4.AstraZeneca, BioPharmaceut R&D, Biosci Cardiovasc Res & Early Dev Cardiovasc Rena, Gothenburg, Sweden;
5.Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Cardiol, Shanghai, Peoples R China;
6.East China Normal Univ, Sch Life Sci, Shanghai, Peoples R China;
7.Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Pediat Cardiol, Shanghai 200092, Peoples R China;
8.UCLA, David Geffen Sch Med, Cardiol, 675 Charles E Young South, Los Angeles, CA 90095 USA
通讯作者单位生命科学与技术学院
推荐引用方式
GB/T 7714
Liu, Xiuxiu,Pu, Wenjuan,He, Lingjuan,et al. Cell proliferation fate mapping reveals regional cardiomyocyte cell-cycle activity in subendocardial muscle of left ventricle[J]. NATURE COMMUNICATIONS,2021,12(1).
APA Liu, Xiuxiu.,Pu, Wenjuan.,He, Lingjuan.,Li, Yan.,Zhao, Huan.,...&Zhou, Bin.(2021).Cell proliferation fate mapping reveals regional cardiomyocyte cell-cycle activity in subendocardial muscle of left ventricle.NATURE COMMUNICATIONS,12(1).
MLA Liu, Xiuxiu,et al."Cell proliferation fate mapping reveals regional cardiomyocyte cell-cycle activity in subendocardial muscle of left ventricle".NATURE COMMUNICATIONS 12.1(2021).
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