A genome-wide association study of facial morphology identifies novel genetic loci in Han Chinese

doi:10.1016/j.jgg.2020.10.004

	A genome-wide association study of facial morphology identifies novel genetic loci in Han Chinese
	Huang, Yin 1; Li, Dan 1,2; Qiao, Lu 1; Liu, Yu 1; Peng, Qianqian 1; Wu, Sijie 1,3,4; Zhang, Manfei 1,3,4; Yang, Yajun 3,4,5; Tan, Jingze 3,4,5; Xu, Shuhua1,6,7,8 ; Jin, Li 1,3,4,5,6; Wang, Sijia 1,6,7; Tang, Kun 1,2; Gruenewald, Stefan 1
	2021-03-20
发表期刊	JOURNAL OF GENETICS AND GENOMICS (IF:6.6[JCR-2023],5.8[5-Year])
ISSN	1673-8527
EISSN	1873-5533
卷号	48 期号:3 页码:198-207
DOI	10.1016/j.jgg.2020.10.004
摘要	The human face is a heritable surface with many complex sensory organs. In recent years, many genetic loci associated with facial features have been reported in different populations, yet there is a lack of studies on the Han Chinese population. Here, we report a genome-wide association study of 3D normal human faces of 2,659 Han Chinese with autosegment phenotypes of facial morphology. We identify single-nucleotide polymorphisms (SNPs) encompassing four genomic regions showing significant associations with different facial regions, including SNPs in DENND1B associated with the chin, SNPs among PISRT1 associated with eyes, SNPs between DCHS2 and SFRP2 associated with the nose, and SNPs in VPS13B associated with the nose. We replicate 24 SNPs from previously reported genetic loci in different populations, whose candidate genes are DCHS2, SUPT3H, HOXD1, SOX9, PAX3, and EDAR. These results provide a more comprehensive understanding of the genetic basis of variation in human facial morphology. Copyright (C) 2020, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.
关键词	Genome-wide association study Facial morphology Automatic phenotyping Visualization
URL	查看原文
收录类别	SCIE
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Genetics & Heredity
WOS类目	Biochemistry & Molecular Biology ; Genetics & Heredity
WOS记录号	WOS:000681047800003
出版者	SCIENCE PRESS
原始文献类型	Review
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/128005
专题	生命科学与技术学院_特聘教授组_徐书华组
通讯作者	Wang, Sijia; Tang, Kun
作者单位	1.Chinese Acad Sci, Univ Chinese Acad Sci, CAS MPG Partner Inst Computat Biol,Key Lab Comput, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; 2.DeepBlue Technol Shanghai Co Ltd, Shanghai 200336, Peoples R China; 3.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China; 4.Fudan Univ, Sch Life Sci, Minist Educ, Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China; 5.Fudan Taizhou Inst Hlth Sci, Taizhou 225300, Peoples R China; 6.Collaborat Innovat Ctr Genet & Dev, Shanghai 200438, Peoples R China; 7.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China; 8.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Huang, Yin,Li, Dan,Qiao, Lu,et al. A genome-wide association study of facial morphology identifies novel genetic loci in Han Chinese[J]. JOURNAL OF GENETICS AND GENOMICS,2021,48(3):198-207.
APA	Huang, Yin.,Li, Dan.,Qiao, Lu.,Liu, Yu.,Peng, Qianqian.,...&Gruenewald, Stefan.(2021).A genome-wide association study of facial morphology identifies novel genetic loci in Han Chinese.JOURNAL OF GENETICS AND GENOMICS,48(3),198-207.
MLA	Huang, Yin,et al."A genome-wide association study of facial morphology identifies novel genetic loci in Han Chinese".JOURNAL OF GENETICS AND GENOMICS 48.3(2021):198-207.