Astrocytic IP(3)Rs: Beyond IP(3)R2
Sherwood, Mark W.1; Arizono, Misa2; Panatier, Aude1; Mikoshiba, Katsuhiko3,4,5; Oliet, Stephane H. R.1
2021-07-30
发表期刊FRONTIERS IN CELLULAR NEUROSCIENCE
ISSN1662-5102
EISSN1662-5102
卷号15
发表状态已发表
DOI10.3389/fncel.2021.695817
摘要

Y Astrocytes are sensitive to ongoing neuronal/network activities and, accordingly, regulate neuronal functions (synaptic transmission, synaptic plasticity, behavior, etc.) by the context-dependent release of several gliotransmitters (e.g., glutamate, glycine, Dserine, ATP). To sense diverse input, astrocytes express a plethora of G-protein coupled receptors, which couple, via Giro and Gq, to the intracellular Ca2+ release channel IP3-receptor (IP3R). Indeed, manipulating astrocytic IP3R-Ca2+ signaling is highly consequential at the network and behavioral level: Depleting IP3R subtype 2 (IP(3)R2) results in reduced GPCR-Ca2+ signaling and impaired synaptic plasticity; enhancing IP3R-Ca2+ signaling affects cognitive functions such as learning and memory, sleep, and mood. However, as a result of discrepancies in the literature, the role of GPCR-IP3R-Ca2+ signaling, especially under physiological conditions, remains inconclusive. One primary reason for this could be that IP3R2 has been used to represent all astrocytic IP(3)Rs, including IP(3)R1 and IP(3)R3. Indeed, IP(3)R1 and IP(3)R3 are unique Ca2+ channels in their own right; they have unique biophysical properties, often display distinct distribution, and are differentially regulated. As a result, they mediate different physiological roles to IP(3)R2. Thus, these additional channels promise to enrich the diversity of spatiotemporal Ca2+ dynamics and provide unique opportunities for integrating neuronal input and modulating astrocyte-neuron communication. The current review weighs evidence supporting the existence of multiple astrocytic-IP3R isoforms, summarizes distinct sub-type specific properties that shape spatiotemporal Ca2+ dynamics. We also discuss existing experimental tools and future refinements to better recapitulate the endogenous activities of each IP3R isoform.

关键词astrocyte inositol triphosphate (IP3) receptor IP3R subtypes calcium GPCR tripartite synapse gliotransmission
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收录类别SCI ; SCIE
语种英语
资助项目Agence Nationale de la Recherche[
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000684959500001
出版者FRONTIERS MEDIA SA
原始文献类型Review
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/128000
专题免疫化学研究所_PI研究组_Katsuhiko Mikoshiba组
通讯作者Sherwood, Mark W.; Arizono, Misa
作者单位1.Univ Bordeaux, Neuroctr Magendie, U1215, INSERM, Bordeaux, France
2.Univ Bordeaux, Interdisciplinary Inst Neurosci, IINS, CNRS,UMR 5297, Bordeaux, France
3.ShanghaiTech Univ, Shanghai, Peoples R China
4.Toho Univ, Fac Sci, Funabashi, Chiba, Japan
5.RIKEN, CLST, Kobe, Hyogo, Japan
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Sherwood, Mark W.,Arizono, Misa,Panatier, Aude,et al. Astrocytic IP(3)Rs: Beyond IP(3)R2[J]. FRONTIERS IN CELLULAR NEUROSCIENCE,2021,15.
APA Sherwood, Mark W.,Arizono, Misa,Panatier, Aude,Mikoshiba, Katsuhiko,&Oliet, Stephane H. R..(2021).Astrocytic IP(3)Rs: Beyond IP(3)R2.FRONTIERS IN CELLULAR NEUROSCIENCE,15.
MLA Sherwood, Mark W.,et al."Astrocytic IP(3)Rs: Beyond IP(3)R2".FRONTIERS IN CELLULAR NEUROSCIENCE 15(2021).
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