DJ-1 in neurodegenerative diseases: Pathogenesis and clinical application

doi:10.1016/j.pneurobio.2021.102114

	DJ-1 in neurodegenerative diseases: Pathogenesis and clinical application
	Huang, Maoxin 1,2; Chen, Shengdi1,2,3
	2021-09
发表期刊	PROGRESS IN NEUROBIOLOGY (IF:6.7[JCR-2023],8.7[5-Year])
ISSN	0301-0082
EISSN	1873-5118
卷号	204
DOI	10.1016/j.pneurobio.2021.102114
摘要	Neurodegenerative diseases (NDs) are one of the major health threats to human characterized by selective and progressive neuronal loss. The mechanisms of NDs are still not fully understood. The study of genetic defects and disease-related proteins offers us a window into the mystery of it, and the extension of knowledge indicates that different NDs share similar features, mechanisms, and even genetic or protein abnormalities. Among these findings, PARK7 and its production DJ-1 protein, which was initially found implicated in PD, have also been found altered in other NDs. PARK7 mutations, altered expression and posttranslational modification (PTM) cause DJ-1 abnormalities, which in turn lead to downstream mechanisms shared by most NDs, such as mitochondrial dysfunction, oxidative stress, protein aggregation, autophagy defects, and so on. The knowledge of DJ-1 derived
关键词	DJ-1 PARK7 Neurodegenerative diseases Pathogenesis Biomarker Therapeutic strategy
收录类别	SCIE
语种	英语
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000684293700004
出版者	PERGAMON-ELSEVIER SCIENCE LTD
原始文献类型	Review
引用统计	被引频次：50[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/127977
专题	免疫化学研究所_特聘教授组_陈生弟组
通讯作者	Chen, Shengdi
作者单位	1.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Neurol, Sch Med, Shanghai 200025, Peoples R China; 2.Shanghai Jiao Tong Univ, Ruijin Hosp, Inst Neurol, Sch Med, Shanghai 200025, Peoples R China; 3.Shanghai Tech Univ, Inst Immunochem, Lab Translat Res Neurodegenerat Dis, Shanghai 201210, Peoples R China
通讯作者单位	上海科技大学
推荐引用方式 GB/T 7714	Huang, Maoxin,Chen, Shengdi. DJ-1 in neurodegenerative diseases: Pathogenesis and clinical application[J]. PROGRESS IN NEUROBIOLOGY,2021,204.
APA	Huang, Maoxin,&Chen, Shengdi.(2021).DJ-1 in neurodegenerative diseases: Pathogenesis and clinical application.PROGRESS IN NEUROBIOLOGY,204.
MLA	Huang, Maoxin,et al."DJ-1 in neurodegenerative diseases: Pathogenesis and clinical application".PROGRESS IN NEUROBIOLOGY 204(2021).