RNA structure probing uncovers RNA structure-dependent biological functions

doi:10.1038/s41589-021-00805-7

	RNA structure probing uncovers RNA structure-dependent biological functions
	Wang, Xi-Wen 1,2; Liu, Chu-Xiao 3; Chen, Ling-Ling3,4,5 ; Zhang, Qiangfeng Cliff 1,2
	2021-07
发表期刊	NATURE CHEMICAL BIOLOGY (IF:12.9[JCR-2023],14.7[5-Year])
ISSN	1552-4450
卷号	17 期号:7 页码:755-766
DOI	10.1038/s41589-021-00805-7
摘要	RNA molecules fold into complex structures that enable their diverse functions in cells. Recent revolutionary innovations in transcriptome-wide RNA structural probing of living cells have ushered in a new era in understanding RNA functions. Here, we summarize the latest technological advances for probing RNA secondary structures and discuss striking discoveries that have linked RNA regulation and biological processes through interrogation of RNA structures. In particular, we highlight how different long noncoding RNAs form into distinct secondary structures that determine their modes of interactions with protein partners to realize their unique functions. These dynamic structures mediate RNA regulatory functions through altering interactions with proteins and other RNAs. We also outline current methodological hurdles and speculate about future directions for development of the next generation of RNA structure-probing technologies of higher sensitivity and resolution, which could then be applied in increasingly physiologically relevant studies.
关键词	LONG NONCODING RNA GENOME-WIDE MEASUREMENT SECONDARY STRUCTURE PROTEIN INTERACTIONS GLOBAL ANALYSIS X-CHROMOSOME LIVING CELLS XIST LNCRNA REVEALS DOMAINS
收录类别	SCIE
语种	英语
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000667912000005
出版者	NATURE RESEARCH
原始文献类型	Review
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/127657
专题	生命科学与技术学院_特聘教授组_陈玲玲组
通讯作者	Chen, Ling-Ling; Zhang, Qiangfeng Cliff
作者单位	1.Tsinghua Univ, Sch Life Sci, Ctr Synthet & Syst Biol,Beijing Adv Innovat Ctr S, Frontier Res Ctr Biol Struct,MOE Key Lab Bioinfor, Beijing, Peoples R China; 2.Tsinghua Peking Ctr Life Sci, Beijing, Peoples R China; 3.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol,State Key Lab M, CAS Ctr Excellence Mol Cell Sci,Shanghai Key Lab, Shanghai, Peoples R China; 4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China; 5.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Hangzhou, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Wang, Xi-Wen,Liu, Chu-Xiao,Chen, Ling-Ling,et al. RNA structure probing uncovers RNA structure-dependent biological functions[J]. NATURE CHEMICAL BIOLOGY,2021,17(7):755-766.
APA	Wang, Xi-Wen,Liu, Chu-Xiao,Chen, Ling-Ling,&Zhang, Qiangfeng Cliff.(2021).RNA structure probing uncovers RNA structure-dependent biological functions.NATURE CHEMICAL BIOLOGY,17(7),755-766.
MLA	Wang, Xi-Wen,et al."RNA structure probing uncovers RNA structure-dependent biological functions".NATURE CHEMICAL BIOLOGY 17.7(2021):755-766.