3D genomics across the tree of life reveals condensin II as a determinant of architecture type

doi:10.1126/science.abe2218

KMS > 免疫化学研究所 > 特聘教授组 > Erez Lieberman Aiden组

	3D genomics across the tree of life reveals condensin II as a determinant of architecture type
	Hoencamp, Claire 1; Dudchenko, Olga 2,3,4; Elbatsh, Ahmed M. O.1,44; Brahmachari, Sumitabha 4; Raaijmakers, Jonne A.5; van Schaik, Tom 6; Cacciatore, Angela Sedeno 1; Contessoto, Vinicius G.4,7; van Heesbeen, Roy G. H. P.5,45; van den Broek, Bram 8; Mhaskar, Aditya N.1,46; Teunissen, Hans 6; St Hilaire, Brian Glenn 2,3; Weisz, David 2,3; Omer, Arina D.2; Pham, Melanie 2; Colaric, Zane 2; Yang, Zhenzhen9 ; Rao, Suhas S. P.2,3,10; Mitra, Namita 2,3; Lui, Christopher 2; Yao, Weijie 2; Khan, Ruqayya 2,3; Moroz, Leonid L.11,12; Kohn, Andrea 11,12; St Leger, Judy 13; Mena, Alexandria 14; Holcroft, Karen 15; Gambetta, Maria Cristina 16; Lim, Fabian 17; Farley, Emma 17; Stein, Nils 18,19,20; Haddad, Alexander 2; Chauss, Daniel 21; Mutlu, Ayse Sena 3; Wang, Meng C.3,22,23; Young, Neil D.24; Hildebrandt, Evin 25,47; Cheng, Hans H.25; Knight, Christopher J.26; Burnham, Theresa L. U.27,28,29; Hovel, Kevin A.28,29; Beel, Andrew J.10; Mattei, Pierre-Jean 10; Kornberg, Roger D.10; Warren, Wesley C.30; Cary, Gregory 31; Gomez-Skarmeta, Jose Luis 32; Hinman, Veronica 33; Lindblad-Toh, Kerstin 34,35; Di Palma, Federica 36; Maeshima, Kazuhiro 37,38; Multani, Asha S.39; Sen Pathak 39; Nel-Themaat, Liesl 39,48; Behringer, Richard R.39; Kaur, Parwinder 20; Medema, Rene H.5; van Steensel, Bas 6; de Wit, Elzo 6; Onuchic, Jose N.4,40,41,42; Di Pierro, Michele 4,43; Aiden, Erez Lieberman2,3,4,9,20,34 ; Rowland, Benjamin D.1
	2021
发表期刊	SCIENCE (IF:44.7[JCR-2023],50.3[5-Year])
ISSN	0036-8075
EISSN	1095-9203
卷号	372 期号:6545 页码:984
DOI	10.1126/science.abe2218
摘要	We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional (3D) genome architectures at the chromosome scale. Each type appears and disappears repeatedly during eukaryotic evolution. The type of genome architecture that an organism exhibits correlates with the absence of condensin II subunits. Moreover, condensin II depletion converts the architecture of the human genome to a state resembling that seen in organisms such as fungi or mosquitoes. In this state, centromeres cluster together at nucleoli, and heterochromatin domains merge. We propose a physical model in which lengthwise compaction of chromosomes by condensin II during mitosis determines chromosome-scale genome architecture, with effects that are retained during the subsequent interphase. This mechanism likely has been conserved since the last common ancestor of all eukaryotes.
收录类别	SCIE
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000656432400051
出版者	AMER ASSOC ADVANCEMENT SCIENCE
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/127617
专题	免疫化学研究所_特聘教授组_Erez Lieberman Aiden组免疫化学研究所_特聘教授组_结构生物化学实验室
通讯作者	Aiden, Erez Lieberman; Rowland, Benjamin D.
作者单位	1.Netherlands Canc Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands; 2.Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA; 3.Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA; 4.Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77005 USA; 5.Netherlands Canc Inst, Oncode Inst, Div Cell Biol, NL-1066 CX Amsterdam, Netherlands; 6.Netherlands Canc Inst, Oncode Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands; 7.Sao Paulo State Univ UNESP, Inst Biosci Letters & Exact Sci, Dept Phys, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil; 8.Netherlands Canc Inst, BioImaging Facil, NL-1066 CX Amsterdam, Netherlands; 9.ShanghaiTech, Shanghai Inst Adv Immunochem Studies, Pudong 201210, Peoples R China; 10.Stanford Univ, Dept Struct Biol, Sch Med, Stanford, CA 94305 USA; 11.Univ Florida, Whitney Lab, Gainesville, FL 32611 USA; 12.Univ Florida, Dept Neurosci, Gainesville, FL 32611 USA; 13.Cornell Univ, Dept Biosci, Coll Vet Med, Ithaca, NY 14853 USA; 14.SeaWorld San Diego, San Diego, CA 92109 USA; 15.Moody Gardens, Galveston, TX 77554 USA; 16.Univ Lausanne, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland; 17.Univ Calif San Diego, Dept Med & Mol Biol, La Jolla, CA 92093 USA; 18.Leibniz Inst Plant Genet & Crop Plant Res IPK Gat, D-06466 Seeland, Germany; 19.Georg August Univ Gottingen, Ctr Integrated Breeding Res CiBreed, Dept Crop Sci, D-37075 Gottingen, Germany; 20.Univ Western Australia, UWA Sch Agr & Environm, Perth, WA 6009, Australia; 21.NIDDK, NIH, Bethesda, MD 20892 USA; 22.Baylor Coll Med, Huffington Ctr Aging, Houston, TX 77030 USA; 23.Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA; 24.Univ Melbourne, Fac Vet & Agr Sci, Parkville, Vic 3010, Australia; 25.ARS, Avian Dis & Oncol Lab, USDA, E Lansing, MI 48823 USA; 26.Stanford Univ, Hopkins Marine Stn, Pacific Grove, CA 93950 USA; 27.Univ Calif Davis, Dept Wildlife Fish & Conservat Biol, Davis, CA 95616 USA; 28.San Diego State Univ, Coastal & Marine Inst, San Diego, CA 92106 USA; 29.San Diego State Univ, Dept Biol, San Diego, CA 92106 USA; 30.Univ Missouri, Dept Anim Sci, Columbia, MO 65211 USA; 31.Jackson Lab, Bar Harbor, ME 04609 USA; 32.Univ Pablo de Olavide, Ctr Andaluz Biol Desarrollo, CSIC, Seville 41013, Spain; 33.Carnegie Mellon Univ, Dept Biol Sci, Pittsburgh, PA 15213 USA; 34.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA; 35.Uppsala Univ, Dept Med Biochem & Microbiol, Sci Life Lab, S-75123 Uppsala, Sweden; 36.Univ East Anglia, Dept Biol Sci, Norwich NR4 7TJ, Norfolk, England; 37.Natl Inst Genet, Genome Dynam Lab, Mishima, Shizuoka 4118540, Japan; 38.Sokendai Grad Univ Adv Studies, Dept Genet, Mishima, Shizuoka 4118540, Japan; 39.Univ Texas MD Anderson Canc Ctr, Dept Genet, Houston, TX 77030 USA; 40.Rice Univ, Dept Phys & Astron, Houston, TX 77005 USA; 41.Rice Univ, Dept Chem, Houston, TX 77005 USA; 42.Rice Univ, Dept Biosci, Houston, TX 77005 USA; 43.Northeastern Univ, Dept Phys, Boston, MA 02115 USA; 44.Novartis Inst Biomed Res, CH-4002 Basel, Switzerland; 45.Janssen Vaccines & Prevent BV, NL-2333 CN Leiden, Netherlands; 46.Univ Med Ctr Rotterdam, Erasmus MC, Dept Dev Biol, NL-3015 GD Rotterdam, Netherlands; 47.Zoetis, VMRD Global Biol Res, Kalamazoo, MI 49007 USA; 48.Univ Colorado Adv Reprod Med, Denver, CO 80238 USA
通讯作者单位	免疫化学研究所
推荐引用方式 GB/T 7714	Hoencamp, Claire,Dudchenko, Olga,Elbatsh, Ahmed M. O.,et al. 3D genomics across the tree of life reveals condensin II as a determinant of architecture type[J]. SCIENCE,2021,372(6545):984.
APA	Hoencamp, Claire.,Dudchenko, Olga.,Elbatsh, Ahmed M. O..,Brahmachari, Sumitabha.,Raaijmakers, Jonne A..,...&Rowland, Benjamin D..(2021).3D genomics across the tree of life reveals condensin II as a determinant of architecture type.SCIENCE,372(6545),984.
MLA	Hoencamp, Claire,et al."3D genomics across the tree of life reveals condensin II as a determinant of architecture type".SCIENCE 372.6545(2021):984.