上海科技大学知识管理系统

本发明涉及医药领域，具体涉及一种抗白血病硒代那可丁衍生物的制备方法及其应用。所述硒代那可丁衍生物的结构通式如通式i或通式ii所示，本发明通过半合成的方法，合成了一系列9位硒代的那可丁衍生物，该合成路线短，实验操作简单，且收率效果好；该制备方法得到的硒代的那可丁衍生物对各种白血病细胞显示出优异的抑制活性，可用于制备高效且低毒的白血病治疗药物，所述R1或R2基团为烷基、环烷基、芳基、杂芳基、氧烷基、酯烷基、烯丙基、炔丙基或氰基。

The invention relates to the field of medicine, in particular to a preparation method and application of an anti-leukemia selenonarcotine derivative. The structural general formula of the selenonarcotine derivative is shown as a general formula i or a general formula ii, whereina series of 9-selenonarcotine derivatives are synthesized through a semi-synthesis method, and the synthesis route is short, and experimental operation is simple, and the yield effect is good; and the seleno narcotine derivative obtained by the preparation method shows excellent inhibitory activity on various leukemia cells and can be used for preparing efficient and low-toxicity leukemia treatment drugs, and the R1 or R2 group is alkyl, naphthenic base, aryl, heteroaryl, oxyalkyl, ester alkyl, allyl, propargyl or cyano.