First Isolation and Confirmation of Sterol Based on beta-sitosterol Skeleton from the Leaves of Podocarpusnagi Planted in Fujian, Preliminary in vitro Anticancer Activity and the Crystal Structure

doi:10.14102/j.cnki.0254-5861.2011-2981

	First Isolation and Confirmation of Sterol Based on beta-sitosterol Skeleton from the Leaves of Podocarpusnagi Planted in Fujian, Preliminary in vitro Anticancer Activity and the Crystal Structure
	Yang Yang1,2,4,5 ; Yong Jian-Ping 3; Olatunde, Olagoke Zacchaeus 1,5; Lu Can-Zhong 1,3,5
	2021-05-12
发表期刊	CHINESE JOURNAL OF STRUCTURAL CHEMISTRY (IF:5.9[JCR-2023],2.1[5-Year])
ISSN	0254-5861
卷号	40 期号:5 页码:653-658
发表状态	已发表
DOI	10.14102/j.cnki.0254-5861.2011-2981
摘要	The crystal of (24R)-3 beta,5 alpha-dihydroxy-24-ethyl-5 alpha-cholestan-6-one (1) was isolated from the leaves of P. nagi planted in Fujian for the first time with the same skeleton as 26,27-dinorcholest-5-en-3-beta-ol (2) and beta-sitosterol (3) that have been reported before. Compound 1 crystallizes in monoclinic, space group P2(1) with a = 10.8482(4), b = 7.3671(3), c = 33.7860(15) angstrom, beta = 93.103(4)degrees, V = 2696.21(19) angstrom(3), Z = 75, M-r = 446.70, rho(calc), = 1.145 g/cm(3), F(000) = 1032, mu = 0.572 mm(-1), GOOF = 1.034, the final R = 0.0467 and wR = 0.1129 for 6989 observed reflections with I > 2 sigma(I). Compound 2 was selected to evaluate for their preliminary in vitro anticancer activity against four cancer cell lines for the first time. The results showed that compound 2 exhibited great inhibition against gastric cancer, breast cancer MCF-7, lung cancer A549 and Helacell lines with the inhibitions of 89.16% +/- 1.17, 97.02%+/- 0.53, 47.20% +/- 2.58 and 36.89%+/- 1.22 respectively at the concentration of 1.4x10(-2) M, which means that we found the new anticancer compound in this plant medicine.
关键词	Podocarpusnagi crystal structure sterols isolation anticancer evaluation
收录类别	SCIE
语种	英语
WOS研究方向	Chemistry ; Crystallography
WOS类目	Chemistry, Inorganic & Nuclear ; Crystallography
WOS记录号	WOS:000651111400015
出版者	CHINESE JOURNAL STRUCTURAL CHEMISTRY
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/126796
专题	物质科学与技术学院_硕士生
通讯作者	Yong Jian-Ping; Lu Can-Zhong
作者单位	1.Chinese Acad Sci, Fujian Inst Res Struct Matter, Haixi Inst, Fuzhou 350002, Peoples R China; 2.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China; 3.Chinese Acad Sci, Xiamen Inst Rare Earth Mat, Haixi Inst, Xiamen 361021, Peoples R China; 4.ShanghaiTech Univ, Shanghai 201210, Peoples R China; 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	上海科技大学
推荐引用方式 GB/T 7714	Yang Yang,Yong Jian-Ping,Olatunde, Olagoke Zacchaeus,et al. First Isolation and Confirmation of Sterol Based on beta-sitosterol Skeleton from the Leaves of Podocarpusnagi Planted in Fujian, Preliminary in vitro Anticancer Activity and the Crystal Structure[J]. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,2021,40(5):653-658.
APA	Yang Yang,Yong Jian-Ping,Olatunde, Olagoke Zacchaeus,&Lu Can-Zhong.(2021).First Isolation and Confirmation of Sterol Based on beta-sitosterol Skeleton from the Leaves of Podocarpusnagi Planted in Fujian, Preliminary in vitro Anticancer Activity and the Crystal Structure.CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,40(5),653-658.
MLA	Yang Yang,et al."First Isolation and Confirmation of Sterol Based on beta-sitosterol Skeleton from the Leaves of Podocarpusnagi Planted in Fujian, Preliminary in vitro Anticancer Activity and the Crystal Structure".CHINESE JOURNAL OF STRUCTURAL CHEMISTRY 40.5(2021):653-658.