ShanghaiTech University Knowledge Management System
| Histone transcription regulator Slm9 is required for cytoophidium biogenesis | |
| 2021-06-01 | |
| 发表期刊 | EXPERIMENTAL CELL RESEARCH (IF:3.3[JCR-2023],3.3[5-Year]) |
| ISSN | 0014-4827 |
| EISSN | 1090-2422 |
| 卷号 | 403期号:1 |
| DOI | 10.1016/j.yexcr.2021.112582 |
| 摘要 | The cytoophidium, a subcellular structure composed of CTP synthase, can be observed during the division of Schizosaccharomyces pombe. Cytoophidium formation changes periodically with the cell cycle of yeast cells. Here, we find that histone chaperone Slm9 is required for the integrity of cytoophidia in fission yeast. When the slm9 gene is knocked out, we observe that morphological characteristics, the abundance of cytoophidia and the division of the yeast cells are significantly affected. Fragmented cytoophidia occur in slm9 mutant cells, a phenomenon rarely observed in wild-type cells. Our study reveals a potential link between a chromosomal regulatory factor and cytoophidium biogenesis. |
| 关键词 | Slm9 CTP synthase Cytoophidium Schizosaccharomyces pombe |
| 收录类别 | SCIE |
| 语种 | 英语 |
| WOS研究方向 | Oncology ; Cell Biology |
| WOS类目 | Oncology ; Cell Biology |
| WOS记录号 | WOS:000645097800004 |
| 出版者 | ELSEVIER INC |
| 原始文献类型 | Article |
| 引用统计 | 正在获取...
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| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/126638 |
| 专题 | 生命科学与技术学院_本科生 生命科学与技术学院_PI研究组_刘冀珑组 |
| 通讯作者 | Liu, Ji-Long |
| 作者单位 | ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China |
| 第一作者单位 | 生命科学与技术学院 |
| 通讯作者单位 | 生命科学与技术学院 |
| 第一作者的第一单位 | 生命科学与技术学院 |
| 推荐引用方式 GB/T 7714 | Feng, Han-Chao,Andreadis, Christos,Liu, Ji-Long. Histone transcription regulator Slm9 is required for cytoophidium biogenesis[J]. EXPERIMENTAL CELL RESEARCH,2021,403(1). |
| APA | Feng, Han-Chao,Andreadis, Christos,&Liu, Ji-Long.(2021).Histone transcription regulator Slm9 is required for cytoophidium biogenesis.EXPERIMENTAL CELL RESEARCH,403(1). |
| MLA | Feng, Han-Chao,et al."Histone transcription regulator Slm9 is required for cytoophidium biogenesis".EXPERIMENTAL CELL RESEARCH 403.1(2021). |
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