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| Progress in human liver organoids | |
| 2020-08 | |
| Source Publication | JOURNAL OF MOLECULAR CELL BIOLOGY
 |
| ISSN | 1674-2788 |
| EISSN | 1759-4685 |
| Volume | 12Issue:8Pages:607-617 |
| DOI | 10.1093/jmcb/mjaa013 |
| Abstract | Understanding the development, regeneration, and disorders of the liver is the major goal in liver biology. Current mechanistic knowledge of human livers has been largely derived from mouse models and cell lines, which fall short in recapitulating the features of human liver cells or the structures and functions of human livers. Organoids as an in vitro system hold the promise to generate organ-like tissues in a dish. Recent advances in human liver organoids also facilitate the understanding of the biology and diseases in this complex organ. Here we review the progress in human liver organoids, mainly focusing on the methods to generate liver organoids, their applications, and possible future directions. |
| Keyword | liver organoid progress perspectives |
| URL | 查看原文 |
| Indexed By | SCI ; SCIE |
| Language | 英语 |
| WOS Research Area | Cell Biology |
| WOS Subject | Cell Biology |
| WOS ID | WOS:000605614000006 |
| Publisher | OXFORD UNIV PRESS |
| WOS Keyword | PLURIPOTENT STEM-CELLS ; HEPATOCYTE-LIKE CELLS ; LONG-TERM EXPANSION ; IN-VITRO ; COLORECTAL-CANCER ; DISEASE ; CHOLANGIOCYTES ; FIBROBLASTS ; HOMEOSTASIS ; GENERATION |
| Original Document Type | Review |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/125995 |
| Collection | 生命科学与技术学院_特聘教授组_惠利健组 |
| Corresponding Author | Hui, Lijian |
| Affiliation | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell,State Key Lab Cell Biol, Shanghai 200031, Peoples R China; 2.Chinese Acad Sci, Biores Innovat Ctr, Shanghai Inst Biochem & Cell Biol, Suzhou 215121, Peoples R China; 3.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China; 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China |
| Corresponding Author Affilication | School of Life Science and Technology |
| Recommended Citation GB/T 7714 | Sun, Lulu,Hui, Lijian. Progress in human liver organoids[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2020,12(8):607-617. |
| APA | Sun, Lulu,&Hui, Lijian.(2020).Progress in human liver organoids.JOURNAL OF MOLECULAR CELL BIOLOGY,12(8),607-617. |
| MLA | Sun, Lulu,et al."Progress in human liver organoids".JOURNAL OF MOLECULAR CELL BIOLOGY 12.8(2020):607-617. |
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