Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution

doi:10.1002/advs.202003941

	Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution
	Sun, Xian 1,2,3; Zhang, Xiaochuan 4,5; Ren, Xiaohong 2; Sun, Hongyu 2; Wu, Li 2; Wang, Caifen 2; Ye, Xiaohui 6,7; York, Peter 8; Gao, Zhaobing 5; Jiang, Hualiang4,5,6,7 ; Zhang, Jiwen 2,3,9; Yin, Xianzhen 1,5
	2021-02
发表期刊	ADVANCED SCIENCE (IF:14.3[JCR-2023],16.3[5-Year])
EISSN	2198-3844
卷号	8 期号:8 页码:#VALUE!
DOI	10.1002/advs.202003941
摘要	The effective pulmonary deposition of inhaled particulate carriers loaded with drugs is a prerequisite for therapeutic effects of drug delivery via inhalation route. Revealing the sophisticated lung scaffold and intrapulmonary distribution of particles at three-dimensional (3D), in-situ, and single-particle level remains a fundamental and critical challenge for dry powder inhalation in pre-clinical research. Here, taking advantage of the micro optical sectioning tomography system, the high-precision cross-scale visualization of entire lung anatomy is obtained. Then, co-localized lung-wide datasets of both cyto-architectures and fluorescent particles are collected at full scale with the resolution down to individual particles. The precise spatial distribution pattern reveals the region-specific distribution and structure-associated deposition of the inhalable particles in lungs, which is undetected by previous methods. Overall, this research delivers comprehensive and high-resolution 3D detection of pulmonary drug delivery vectors and provides a novel strategy to evaluate materials distribution for drug delivery.
关键词	dry powder inhalation fluorescence‐ micro optical sectioning tomography inhaled materials pulmonary drug delivery three‐ dimensional rendering
收录类别	SCI ; EI ; SCIE
语种	英语
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000615815600001
出版者	WILEY
WOS关键词	PULMONARY DRUG-DELIVERY ; CELLS ; ATLAS ; MICE
原始文献类型	Article; Early Access
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/125813
专题	免疫化学研究所_特聘教授组_蒋华良组
通讯作者	Jiang, Hualiang; Zhang, Jiwen; Yin, Xianzhen
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr MOST & Image Fus Anal, Shanghai 201210, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 6.Univ Sci & Technol China, Sch Informat Sci & Technol, Hefei 230027, Peoples R China; 7.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai Inst Adv Immunochem Studies, Shanghai 200031, Peoples R China; 8.Univ Bradford, Sch Pharm, Bradford BD7 1DP, W Yorkshire, England; 9.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, Beijing 100050, Peoples R China
通讯作者单位	免疫化学研究所
推荐引用方式 GB/T 7714	Sun, Xian,Zhang, Xiaochuan,Ren, Xiaohong,et al. Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution[J]. ADVANCED SCIENCE,2021,8(8):#VALUE!.
APA	Sun, Xian.,Zhang, Xiaochuan.,Ren, Xiaohong.,Sun, Hongyu.,Wu, Li.,...&Yin, Xianzhen.(2021).Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution.ADVANCED SCIENCE,8(8),#VALUE!.
MLA	Sun, Xian,et al."Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution".ADVANCED SCIENCE 8.8(2021):#VALUE!.