Lactate anions participate in T cell cytokine production and function

doi:10.1007/s11427-020-1887-7

	Lactate anions participate in T cell cytokine production and function
	Wen, Jing1,2,5 ; Cheng, Shipeng 2,5; Zhang, Yaguang 2; Wang, Ran 3; Xu, Jiefang 3; Ling, Zhiyang 2; Ma, Liyan 2; Ai, Xinghao 4; Sun, Bing1,2
	2021-11
发表期刊	SCIENCE CHINA-LIFE SCIENCES (IF:8.0[JCR-2023],7.3[5-Year])
ISSN	1674-7305
EISSN	1869-1889
卷号	64 期号:11 页码:#VALUE!
DOI	10.1007/s11427-020-1887-7
摘要	After antigen stimulation, T cells preferentially increase aerobic glycolysis to meet the bioenergetic and biosynthetic demands of T cell activation, proliferation, and effector functions. Lactate, a by-product of glycolysis, has been reported to function as an important energy source and signaling molecule. Here, we found that lactate anions are involved in cytokine production in T cells after TCR activation. During ex vivo T cell activation, the addition of excess sodium lactate (NaL) increased the production of cytokines (such as IFN gamma/IL-2/TNF alpha) more than the addition of sodium chloride (NaCl). This enhanced cytokine production was dependent on TCR/CD3 activation but not CD28 activation. In vivo, NaL treatment inhibited tumour growth in subcutaneously transplanted tumour models in a T cell-dependent manner, which was consistent with increased T cell cytokine production in the NaL treatment group compared to the NaCl treatment group. Furthermore, a mechanistic experiment showed that this enhanced cytokine production was regulated by GAPDH-mediated post-transcriptional regulation. Taken together, our findings indicate a new regulatory mechanism involved in glycolysis that promotes T cell function.
关键词	lactate glycolysis TCR activation immunometabolism
收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Life Sciences & Biomedicine - Other Topics
WOS类目	Biology
WOS记录号	WOS:000617410100004
出版者	SCIENCE PRESS
原始文献类型	Article; Early Access
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/125809
专题	生命科学与技术学院_特聘教授组_孙兵组生命科学与技术学院_博士生
通讯作者	Zhang, Yaguang; Ai, Xinghao; Sun, Bing
作者单位	1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 2.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China; 3.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Peoples R China; 4.Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Shanghai Lung Canc Ctr, Shanghai 200030, Peoples R China; 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Wen, Jing,Cheng, Shipeng,Zhang, Yaguang,et al. Lactate anions participate in T cell cytokine production and function[J]. SCIENCE CHINA-LIFE SCIENCES,2021,64(11):#VALUE!.
APA	Wen, Jing.,Cheng, Shipeng.,Zhang, Yaguang.,Wang, Ran.,Xu, Jiefang.,...&Sun, Bing.(2021).Lactate anions participate in T cell cytokine production and function.SCIENCE CHINA-LIFE SCIENCES,64(11),#VALUE!.
MLA	Wen, Jing,et al."Lactate anions participate in T cell cytokine production and function".SCIENCE CHINA-LIFE SCIENCES 64.11(2021):#VALUE!.