Deconstructing and reconstructing the human brain with regionally specified brain organoids

doi:10.1016/j.semcdb.2020.05.023

	Deconstructing and reconstructing the human brain with regionally specified brain organoids
	Xiang, Yangfei1,2 ; Cakir, Bilal 1; Park, In-Hyun 1
	2021-03
发表期刊	SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (IF:6.2[JCR-2023],6.9[5-Year])
ISSN	1084-9521
EISSN	1096-3634
卷号	111 页码:40-51
DOI	10.1016/j.semcdb.2020.05.023
摘要	Brain organoids, three-dimensional neural cultures recapitulating the spatiotemporal organization and function of the brain in a dish, offer unique opportunities for investigating the human brain development and diseases. To model distinct parts of the brain, various region-specific human brain organoids have been developed. In this article, we review current approaches to produce human region-specific brain organoids, developed through the endeavor of many researchers. We highlight the applications of human region-specific brain organoids, especially in reconstructing regional interactions in the brain through organoid fusion. We also outline the existing challenges to drive forward further the brain organoid technology and its applications for future studies.
关键词	Brain organoid Region-specific Differentiation Organoid fusion Development Disease modeling Interneuron Thalamus Cell migration Axonal connection Human pluripotent stem cells Embryonic stem cells Induced pluripotent stem cells ATAC-seq
收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Cell Biology ; Developmental Biology
WOS类目	Cell Biology ; Developmental Biology
WOS记录号	WOS:000621820600006
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
原始文献类型	Review
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/125757
专题	生命科学与技术学院_PI研究组_向阳飞组
通讯作者	Xiang, Yangfei; Park, In-Hyun
作者单位	1.Yale Sch Med, Yale Stem Cell Ctr, Dept Genet, New Haven, CT 06520 USA; 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Xiang, Yangfei,Cakir, Bilal,Park, In-Hyun. Deconstructing and reconstructing the human brain with regionally specified brain organoids[J]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY,2021,111:40-51.
APA	Xiang, Yangfei,Cakir, Bilal,&Park, In-Hyun.(2021).Deconstructing and reconstructing the human brain with regionally specified brain organoids.SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY,111,40-51.
MLA	Xiang, Yangfei,et al."Deconstructing and reconstructing the human brain with regionally specified brain organoids".SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY 111(2021):40-51.