ShanghaiTech University Knowledge Management System
| G protein-coupled receptors: structure- and function-based drug discovery | |
| 2021 | |
| Source Publication | SIGNAL TRANSDUCTION AND TARGETED THERAPY
 |
| ISSN | 2095-9907 |
| EISSN | 2059-3635 |
| Volume | 6Issue:1Pages:7 |
| Status | 已发表 |
| DOI | 10.1038/s41392-020-00435-w |
| Abstract | As one of the most successful therapeutic target families, G protein-coupled receptors (GPCRs) have experienced a transformation from random ligand screening to knowledge-driven drug design. We are eye-witnessing tremendous progresses made recently in the understanding of their structure-function relationships that facilitated drug development at an unprecedented pace. This article intends to provide a comprehensive overview of this important field to a broader readership that shares some common interests in drug discovery. |
| URL | 查看原文 |
| Indexed By | SCI ; SCIE |
| Language | 英语 |
| WOS Research Area | Biochemistry & Molecular Biology ; Cell Biology |
| WOS Subject | Biochemistry & Molecular Biology ; Cell Biology |
| Publisher | SPRINGERNATURE, CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND |
| WOS Keyword | MS-binding assays ; Selection-mass spectrometry ; Cryo-EM structure ; Crystallizing membrane-proteins ; Molecular-orbital method ; Glucagon-like peptide-1 ; Allosteric modulation ; GLP-1 receptor ; Biased agonism ; Adenosine A(1) |
| Original Document Type | Review |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/125238 |
| Collection | iHuman研究所_PI研究组_水雯箐组 生命科学与技术学院_特聘教授组_王明伟组 iHuman研究所_PI研究组_陶厚朝组 iHuman研究所_PI研究组_赵素文组 iHuman研究所_PI研究组_程建军组 生命科学与技术学院_博士生 |
| Corresponding Author | Shui, Wenqing; Jiang, Yi; Wang, Ming-Wei |
| Affiliation | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 3.Fudan Univ, Sch Basic Med Sci, Shanghai 200032, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 7.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China |
| Corresponding Author Affilication | iHuman Institute; School of Life Science and Technology |
| Recommended Citation GB/T 7714 | Yang, Dehua,Zhou, Qingtong,Labroska, Viktorija,et al. G protein-coupled receptors: structure- and function-based drug discovery[J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY,2021,6(1):7. |
| APA | Yang, Dehua.,Zhou, Qingtong.,Labroska, Viktorija.,Qin, Shanshan.,Darbalaei, Sanaz.,...&Wang, Ming-Wei.(2021).G protein-coupled receptors: structure- and function-based drug discovery.SIGNAL TRANSDUCTION AND TARGETED THERAPY,6(1),7. |
| MLA | Yang, Dehua,et al."G protein-coupled receptors: structure- and function-based drug discovery".SIGNAL TRANSDUCTION AND TARGETED THERAPY 6.1(2021):7. |
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