Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis

doi:10.1038/s41467-020-19874-8

	Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis
	Wang, Chi 1,2,3; Liu, Hui 1,2,3; Li, Kun 1,2; Wu, Zhen-Zhen 1,2; Wu, Chen 1,2,3; Yu, Jing-Ying 1,2; Gong, Qian 1,2; Fang, Ping 1,2; Wang, Xing-Xing 4; Duan, Shu-Min 3; Wang, Hao 3; Gu, Yan 5,6; Hu, Ji7 ; Pan, Bing-Xing 8; Schmidt, Mathias V.9; Liu, Yi-Jun 1,2; Wang, Xiao-Dong 1,2,3,9
	2020-12-27
发表期刊	NATURE COMMUNICATIONS (IF:14.7[JCR-2023],16.1[5-Year])
ISSN	2041-1723
卷号	11 期号:1
发表状态	已发表
DOI	10.1038/s41467-020-19874-8
摘要	Touch can positively influence cognition and emotion, but the underlying mechanisms remain unclear. Here, we report that tactile experience enrichment improves memory and alleviates anxiety by remodeling neurons along the dorsoventral axis of the dentate gyrus (DG) in adult mice. Tactile enrichment induces differential activation and structural modification of neurons in the dorsal and ventral DG, and increases the presynaptic input from the lateral entorhinal cortex (LEC), which is reciprocally connected with the primary somatosensory cortex (S1), to tactile experience-activated DG neurons. Chemogenetic activation of tactile experience-tagged dorsal and ventral DG neurons enhances memory and reduces anxiety respectively, whereas inactivation of these neurons or S1-innervated LEC neurons abolishes the beneficial effects of tactile enrichment. Moreover, adulthood tactile enrichment attenuates early-life stress-induced memory deficits and anxiety-related behavior. Our findings demonstrate that enriched tactile experience retunes the pathway from S1 to DG and enhances DG neuronal plasticity to modulate cognition and emotion.
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收录类别	SCI ; SCIE
语种	英语
资助项目	National Key Research and Development Program of China[2016YFA0501000] ; National Natural Science Foundation of China[81761138044][81971260]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000596476900022
出版者	NATURE RESEARCH
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/124693
专题	生命科学与技术学院_PI研究组_胡霁组
通讯作者	Wang, Xiao-Dong
作者单位	1.Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Neurobiol, Hangzhou 310058, Peoples R China 2.Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Psychiat, Hangzhou 310058, Peoples R China 3.Zhejiang Univ, NHC & CAMS Key Lab Med Neurobiol, MOE Frontier Sci Ctr Brain Res & Brain Machine In, Sch Brain Sci & Brain Med, Hangzhou 310058, Peoples R China 4.Tech Univ Munich, Klinikum Rechts Isar, Dept Anesthesiol, D-81675 Munich, Germany 5.Zhejiang Univ, Sch Med, Ctr Stem Cell & Regenerat Med, Hangzhou 310058, Peoples R China 6.Zhejiang Univ, Sch Med, Dept Neurol, Affiliated Hosp 2, Hangzhou 310058, Peoples R China 7.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 8.Nanchang Univ, Inst Life Sci, Lab Fear & Anxiety Disorders, Nanchang 330031, Jiangxi, Peoples R China 9.Max Planck Inst Psychiat, D-80804 Munich, Germany
推荐引用方式 GB/T 7714	Wang, Chi,Liu, Hui,Li, Kun,et al. Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis[J]. NATURE COMMUNICATIONS,2020,11(1).
APA	Wang, Chi.,Liu, Hui.,Li, Kun.,Wu, Zhen-Zhen.,Wu, Chen.,...&Wang, Xiao-Dong.(2020).Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis.NATURE COMMUNICATIONS,11(1).
MLA	Wang, Chi,et al."Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis".NATURE COMMUNICATIONS 11.1(2020).