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| Nuclear Morphological Remodeling in Human Granulocytes Is Linked to Prenylation Independently from Cytoskeleton | |
| 2020-11 | |
| Source Publication | CELLS
 |
| Volume | 9Issue:11 |
| Status | 已发表 |
| DOI | 10.3390/cells9112509 |
| Abstract | Nuclear shape modulates cell behavior and function, while aberrant nuclear morphologies correlate with pathological phenotype severity. Nevertheless, functions of specific nuclear morphological features and underlying molecular mechanisms remain poorly understood. Here, we investigate a nucleus-intrinsic mechanism driving nuclear lobulation and segmentation concurrent with granulocyte specification, independently from extracellular forces and cytosolic cytoskeleton contributions. Transcriptomic regulation of cholesterol biosynthesis is equally concurrent with nuclear remodeling. Its putative role as a regulatory element is supported by morphological aberrations observed upon pharmacological impairment of several enzymatic steps of the pathway, most prominently the sterol increment 14-reductase activity of laminB-receptor and protein prenylation. Thus, we support the hypothesis of a nuclear-intrinsic mechanism for nuclear shape control with the putative involvement of the recently discovered GGTase III complex. Such process could be independent from or complementary to the better studied cytoskeleton-based nuclear remodeling essential for cell migration in both physiological and pathological contexts such as immune system function and cancer metastasis. |
| Keyword | nuclear morphology granulocyte lobulation nuclear segmentation prenylation GGTase III |
| URL | 查看原文 |
| Indexed By | SCI ; SCIE |
| Language | 英语 |
| Funding Project | ShanghaiTech University[F-0301-15-009] ; Oak Foundation Award[W1095/OCAY-14-191] |
| WOS Research Area | Cell Biology |
| WOS Subject | Cell Biology |
| WOS ID | WOS:000593518900001 |
| Publisher | MDPI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/124692 |
| Collection | 免疫化学研究所_特聘教授组_生物工程学实验室 免疫化学研究所_特聘教授组_干细胞生物学实验室 免疫化学研究所_特聘教授组_功能筛选实验室 生命科学与技术学院_硕士生 生命科学与技术学院_博士生 免疫化学研究所_特聘教授组_Michael Levitt组 免疫化学研究所_特聘教授组_张宏恺组 |
| Corresponding Author | Elvassore, Nicola |
| Affiliation | 1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies SIAIS, Shanghai 201210, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China 4.CNR, Inst Neurosci, I-35127 Padua, Italy 5.Univ Padua, Dept Ind Engn, I-35131 Padua, Italy 6.Venetian Inst Mol Med, I-35129 Padua, Italy 7.UCL Great Ormond St Inst Child Hlth, Stem Cells & Regenerat Med Sect, London WC1N 1EH, England |
| First Author Affilication | Shanghai Institute for Advanced Immunochemical Studies |
| Corresponding Author Affilication | Shanghai Institute for Advanced Immunochemical Studies |
| First Signature Affilication | Shanghai Institute for Advanced Immunochemical Studies |
| Recommended Citation GB/T 7714 | Martewicz, Sebastian,Luni, Camilla,Zhu, Xi,et al. Nuclear Morphological Remodeling in Human Granulocytes Is Linked to Prenylation Independently from Cytoskeleton[J]. CELLS,2020,9(11). |
| APA | Martewicz, Sebastian.,Luni, Camilla.,Zhu, Xi.,Cui, Meihua.,Hu, Manli.,...&Elvassore, Nicola.(2020).Nuclear Morphological Remodeling in Human Granulocytes Is Linked to Prenylation Independently from Cytoskeleton.CELLS,9(11). |
| MLA | Martewicz, Sebastian,et al."Nuclear Morphological Remodeling in Human Granulocytes Is Linked to Prenylation Independently from Cytoskeleton".CELLS 9.11(2020). |
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