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Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging | |
2020 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
卷号 | 11期号:1页码:5699 |
发表状态 | 已发表 |
DOI | 10.1038/s41467-020-19510-5 |
摘要 | G-protein-coupled receptors (GPCRs) play important roles in cellular functions. However, their intracellular organization is largely unknown. Through investigation of the cannabinoid receptor 1 (CB1), we discovered periodically repeating clusters of CB1 hotspots within the axons of neurons. We observed these CB1 hotspots interact with the membrane-associated periodic skeleton (MPS) forming a complex crucial in the regulation of CB1 signaling. Furthermore, we found that CB1 hotspot periodicity increased upon CB1 agonist application, and these activated CB1 displayed less dynamic movement compared to non-activated CB1. Our results suggest that CB1 forms periodic hotspots organized by the MPS as a mechanism to increase signaling efficacy upon activation. Despite the importance of G-protein-coupled receptors in many cellular functions, their intracellular organisation is largely unknown. The authors identified periodically repeating clusters of cannabinoid receptor 1 hotspots within neuronal axons that are dynamically regulated by CB1 agonists. |
URL | 查看原文 |
收录类别 | SCI ; SCIE |
资助项目 | National Key Research and Development Program of China[2016YFC0905900][2017YFC 1001300] ; National Natural Science Foundation of China[81970878][31871036][31771130][81861128023] ; Australian Research Council[DE170100546] |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000593975100001 |
出版者 | NATURE RESEARCH |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/124688 |
专题 | iHuman研究所_PI研究组_刘志杰组 生命科学与技术学院_PI研究组_林照博组 iHuman研究所 iHuman研究所_公共科研平台_超分辨生物成像平台 iHuman研究所_PI研究组_钟桂生组 iHuman研究所_PI研究组_水雯箐组 iHuman研究所_PI研究组_Garth John Thompson组 生命科学与技术学院_硕士生 生命科学与技术学院_博士生 生命科学与技术学院_PI研究组_王彤组 iHuman研究所_PI研究组_华甜组 |
通讯作者 | Zhong, Guisheng |
作者单位 | 1.ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 4.Dalhousie Univ, Dept Med Neurosci, Halifax, NS B3H 4R2, Canada |
第一作者单位 | iHuman研究所 |
通讯作者单位 | iHuman研究所; 生命科学与技术学院 |
第一作者的第一单位 | iHuman研究所 |
推荐引用方式 GB/T 7714 | Li, Hui,Yang, Jie,Tian, Cuiping,et al. Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging[J]. NATURE COMMUNICATIONS,2020,11(1):5699. |
APA | Li, Hui.,Yang, Jie.,Tian, Cuiping.,Diao, Min.,Wang, Quan.,...&Zhong, Guisheng.(2020).Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging.NATURE COMMUNICATIONS,11(1),5699. |
MLA | Li, Hui,et al."Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging".NATURE COMMUNICATIONS 11.1(2020):5699. |
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