Integrated Omics of Metastatic Colorectal Cancer

doi:10.1016/j.ccell.2020.08.002

	Integrated Omics of Metastatic Colorectal Cancer
	Li, Chen 1,8; Sun, Yi-Di 1,9; Yu, Guan-Yu 2; Cui, Jing-Ru 1; Lou, Zheng 2; Zhang, Hang 2; Huang, Ya1,4 ; Bai, Chen-Guang 10; Deng, Lu-Lu 10; Liu, Peng 2; Zheng, Kuo 2; Wang, Yan-Hua1,4 ; Wang, Qin-Qin1,4 ; Li, Qing-Run 1; Wu, Qing-Qing 1; Liu, Qi 5,6; Shyr, Yu 5,6; Li, Yi-Xue3,4,7 ; Chen, Luo-Nan1,3,4 ; Wu, Jia-Rui1,3,4 ; Zhang, Wei 2; Zeng, Rong1,3,4
	2020-11-09
发表期刊	CANCER CELL (IF:48.8[JCR-2023],42.1[5-Year])
ISSN	1535-6108
卷号	38 期号:5 页码:734-+
发表状态	已发表
DOI	10.1016/j.ccell.2020.08.002
摘要	We integrate the genomics, proteomics, and phosphoproteomics of 480 clinical tissues from 146 patients in a Chinese colorectal cancer (CRC) cohort, among which 70 had metastatic CRC (mCRC). Proteomic profiling differentiates three CRC subtypes characterized by distinct clinical prognosis and molecular signatures. Proteomic and phosphoproteomic profiling of primary tumors alone successfully distinguishes cases with metastasis. Metastatic tissues exhibit high similarities with primary tumors at the genetic but not the proteomic level, and kinase network analysis reveals significant heterogeneity between primary colorectal tumors and their liver metastases. In vivo xenograft-based drug tests using 31 primary and metastatic tumors show personalized responses, which could also be predicted by kinase-substrate network analysis no matter whether tumors carry mutations in the drug-targeted genes. Our study provides a valuable resource for better understanding of mCRC and has potential for clinical application.
收录类别	SCI ; SCIE
语种	英语
资助项目	National Key Research and Development Programme of China[2017YFA0505500] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDA12010000][XDB38000000] ; National Natural Science Foundation of China (NSFC)[91029301][30700397][91529303][31771476][81572358]
WOS研究方向	Oncology ; Cell Biology
WOS类目	Oncology ; Cell Biology
WOS记录号	WOS:000589896200020
出版者	CELL PRESS
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/124686
专题	生命科学与技术学院_硕士生生命科学与技术学院生命科学与技术学院_特聘教授组_曾嵘组生命科学与技术学院_特聘教授组_陈洛南组生命科学与技术学院_特聘教授组_李亦学组生命科学与技术学院_博士生上海临床研究中心
通讯作者	Wu, Jia-Rui; Zhang, Wei; Zeng, Rong
作者单位	1.Chinese Acad Sci, Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, CAS Key Lab Syst Biol, Shanghai 200031, Peoples R China 2.Naval Med Univ, Changhai Hosp, Colorectal Surg Dept, Shanghai 200433, Peoples R China 3.Univ Chinese Acad Sci, Chinese Acad Sci, Hangzhou Inst Adv Study, CAS Key Lab Syst Biol, Hangzhou 310024, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 5.Vanderbilt Univ, Dept Biostat, Sch Med, Nashville, TN 37232 USA 6.Vanderbilt Univ, Ctr Quantitat Sci, Sch Med, Nashville, TN 37232 USA 7.Univ Chinese Acad Sci, Chinese Acad Sci, Biomed Big Data Ctr,Shanghai Inst Nutr & Hlth, Key Lab Computat Biol,CAS MPG Partner Inst Comput, Shanghai 200031, Peoples R China 8.Shanghai Jiao Tong Univ, Ctr Single Cell Omics, Sch Publ Hlth, Sch Med, Shanghai 200025, Peoples R China 9.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Neurosci, Shanghai 200031, Peoples R China 10.Naval Med Univ, Changhai Hosp, Dept Pathol, Shanghai 200433, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Li, Chen,Sun, Yi-Di,Yu, Guan-Yu,et al. Integrated Omics of Metastatic Colorectal Cancer[J]. CANCER CELL,2020,38(5):734-+.
APA	Li, Chen.,Sun, Yi-Di.,Yu, Guan-Yu.,Cui, Jing-Ru.,Lou, Zheng.,...&Zeng, Rong.(2020).Integrated Omics of Metastatic Colorectal Cancer.CANCER CELL,38(5),734-+.
MLA	Li, Chen,et al."Integrated Omics of Metastatic Colorectal Cancer".CANCER CELL 38.5(2020):734-+.