PHF14 is required for germinal center B cell development

doi:10.1016/j.cellimm.2020.104221

	PHF14 is required for germinal center B cell development
	Zhang, Le 1,2; Lu, Yanlai 1; Wang, Yuliang 1; Wang, Feng 2; Zhai, Sulan 1; Chen, Zhengjun3,4 ; Cai, Zhenming 1
	2020-12
发表期刊	CELLULAR IMMUNOLOGY (IF:3.7[JCR-2023],4.1[5-Year])
ISSN	0008-8749
卷号	358
发表状态	已发表
DOI	10.1016/j.cellimm.2020.104221
摘要	Germinal centers (GCs), which are the site of antibody diversification and affinity maturation, are vitally important for humoral immunity. GC B cell proliferation is essentially for these processes by providing enough templates for somatic hypermutation (SHM) and serving as a critical mechanism of positive selection. In the current study, we found a significant reduction of GC response in the spleens of GC B cell specific PHF14 knockout (PHF14(GCB KO)) mice compared with the wild-type control (PHF14(GCB WT)) when the mice were challenged with SRBCs or lymphocytic choriomeningitis virus. We also demonstrated that PHF14 did not affect the cell survival of GC B cells, but regulated the proliferation of GC B cells. In addition, PHF14 suppressed the expression of Cdkn1a (p21) though regulating the level of H3K4me3 to control the proliferation of GC B cells. Collectively, our data suggest that PHF14 plays an important role in the process of germinal center formation by regulating GC B cell proliferation in spleen.
关键词	PHF14 Germinal center Proliferation p21
收录类别	SCI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China[81701542] ; Natural Science Foundation of Jiangsu Province[BK20171059]
WOS研究方向	Cell Biology ; Immunology
WOS类目	Cell Biology ; Immunology
WOS记录号	WOS:000588273500006
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/124324
专题	生命科学与技术学院_特聘教授组_陈正军组
通讯作者	Cai, Zhenming
作者单位	1.Nanjing Med Univ, Dept Immunol, Key Lab Immune Microenvironm & Dis, Nanjing 211166, Peoples R China 2.Nanjing Med Univ, Anal Ctr, Nanjing 211166, Peoples R China 3.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China 4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Le,Lu, Yanlai,Wang, Yuliang,et al. PHF14 is required for germinal center B cell development[J]. CELLULAR IMMUNOLOGY,2020,358.
APA	Zhang, Le.,Lu, Yanlai.,Wang, Yuliang.,Wang, Feng.,Zhai, Sulan.,...&Cai, Zhenming.(2020).PHF14 is required for germinal center B cell development.CELLULAR IMMUNOLOGY,358.
MLA	Zhang, Le,et al."PHF14 is required for germinal center B cell development".CELLULAR IMMUNOLOGY 358(2020).