Optimization of a Decatungstate-Catalyzed C(sp(3))-H Alkylation Using a Continuous Oscillatory Millistructured Photoreactor

doi:10.1021/acs.oprd.0c00235

	Optimization of a Decatungstate-Catalyzed C(sp(3))-H Alkylation Using a Continuous Oscillatory Millistructured Photoreactor
	Wen, Zhenghui 1; Maheshwari, Apoorva 1; Sambiagio, Carlo 1; Deng, Yuchao1,2,3 ; Laudadio, Gabriele 1; Van Aken, Koen 4,5; Sun, Yuhan2,3 ; Gemoets, Hannes P. L.4; Noel, Timothy 1
	2020-10-16
发表期刊	ORGANIC PROCESS RESEARCH & DEVELOPMENT (IF:3.1[JCR-2023],3.4[5-Year])
ISSN	1083-6160
卷号	24 期号:10 页码:2356-2361
发表状态	已发表
DOI	10.1021/acs.oprd.0c00235
摘要	Tetrabutylammonium decatungstate (TBADT) has emerged as an efficient and versatile photocatalyst for hydrogen atom transfer (HAT) processes that enables the cleavage of both activated and unactivated aliphatic C-H bonds. Using a recently developed oscillatory millistructured continuous-flow photoreactor, investigations of a decatungstate-catalyzed C(sp(3))-H alkylation protocol were carried out, and the results are presented here. The performance of the reactor was evaluated in correlation to several chemical and process parameters, including residence time, light intensity, catalyst loading, and substrate/reagent concentration. In comparison with previously reported batch and flow protocols, conditions were found that led to considerably higher productivity, achieving a throughput up to 36.7 mmol/h with a residence time of only 7.5 min.
关键词	hydrogen atom transfer C-H functionalization photocatalysis decatungstate flow photochemistry process intensification
收录类别	SCI ; SCIE ; EI
资助项目	European Union[794072] ; Dutch Science Foundation (NWO)[14150] ; COST Action[CA15106]
WOS研究方向	Chemistry
WOS类目	Chemistry, Applied ; Chemistry, Organic
WOS记录号	WOS:000582583300060
出版者	AMER CHEMICAL SOC
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/124308
专题	物质科学与技术学院_博士生物质科学与技术学院_特聘教授组_孙予罕组
通讯作者	Noel, Timothy
作者单位	1.Eindhoven Univ Technol, Dept Chem Engn & Chem Micro Flow Chem & Synthet M, NL-5612 AZ Eindhoven, Netherlands 2.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China 3.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China 4.Creaflow BV, B-9800 Deinze, Belgium 5.Ecosynth NV, B-9800 Deinze, Belgium
推荐引用方式 GB/T 7714	Wen, Zhenghui,Maheshwari, Apoorva,Sambiagio, Carlo,et al. Optimization of a Decatungstate-Catalyzed C(sp(3))-H Alkylation Using a Continuous Oscillatory Millistructured Photoreactor[J]. ORGANIC PROCESS RESEARCH & DEVELOPMENT,2020,24(10):2356-2361.
APA	Wen, Zhenghui.,Maheshwari, Apoorva.,Sambiagio, Carlo.,Deng, Yuchao.,Laudadio, Gabriele.,...&Noel, Timothy.(2020).Optimization of a Decatungstate-Catalyzed C(sp(3))-H Alkylation Using a Continuous Oscillatory Millistructured Photoreactor.ORGANIC PROCESS RESEARCH & DEVELOPMENT,24(10),2356-2361.
MLA	Wen, Zhenghui,et al."Optimization of a Decatungstate-Catalyzed C(sp(3))-H Alkylation Using a Continuous Oscillatory Millistructured Photoreactor".ORGANIC PROCESS RESEARCH & DEVELOPMENT 24.10(2020):2356-2361.