IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages

doi:10.1038/s41418-020-00650-6

	IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages
	Rao, Li-Zong 1,2; Wang, Yi 2; Zhang, Lei 2; Wu, Guorao 2; Zhang, Lu 2; Wang, Fa-Xi 2; Chen, Long-Min 2; Sun, Fei 2; Jia, Song 2; Zhang, Shu 2; Yu, Qilin 2; Wei, Jiang-Hong 3; Lei, Hui-Ren 3; Yuan, Ting 2,3; Li, Jinxiu 4; Huang, Xingxu5 ; Cheng, Bin 6; Zhao, Jianping 2; Xu, Yongjian 2; Mo, Bi-Wen 3; Wang, Cong-Yi 2; Zhang, Huilan 2
	2021-04
发表期刊	CELL DEATH AND DIFFERENTIATION (IF:13.7[JCR-2023],13.7[5-Year])
ISSN	1350-9047
发表状态	已发表
DOI	10.1038/s41418-020-00650-6
摘要	Idiopathic pulmonary fibrosis (IPF) is the most common type of idiopathic interstitial pneumonia and has one of the poorest prognosis. However, the molecular mechanisms underlying IPF progression remain largely unknown. In this study, we determined that IL-24, an IL-20 subfamily cytokine member, was increased both in the serum of IPF patients and the bronchoalveolar lavage fluid (BALF) of mice following bleomycin (BLM)-induced pulmonary fibrosis. As a result, IL-24 deficiency protected mice from BLM-induced lung injury and fibrosis. Specifically, loss of IL-24 significantly attenuated transforming growth factor beta 1 (TGF-beta 1) production and reduced M2 macrophage infiltration in the lung of BLM-induced mice. Mechanistically, IL-24 alone did not show a perceptible impact on the induction of M2 macrophages, but it synergized with IL-4 to promote M2 program in macrophages. IL-24 suppressed IL-4-induced expression of suppressor of cytokine signaling 1 (SOCS1) and SOCS3, through which it enhanced signal transducer and activator of transcription 6/peroxisome proliferator-activated receptor gamma (STAT6/PPAR gamma) signaling, thereby promoting IL-4-induced production of M2 macrophages. Collectively, our data support that IL-24 synergizes with IL-4 to promote macrophage M2 program contributing to the development of pulmonary fibrosis.
收录类别	SCI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China[81530024][9174927][81920108009][81770823][81760008][81800068][81670929] ; Ministry of Science and Technology[2016YFC1305002][2017YFC1309603] ; NHC Drug Discovery Program[2017ZX09304022-07] ; Department of Science and Technology of Hubei State[2017ACA096] ; Guangxi Natural Science Foundation Program[2018GXNSFDA 281041]
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:000584979000001
出版者	SPRINGERNATURE
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/123975
专题	生命科学与技术学院_PI研究组_黄行许组
通讯作者	Mo, Bi-Wen; Wang, Cong-Yi; Zhang, Huilan
作者单位	1.Cent South Univ, Xiangya Hosp, Key Lab Natl Clin Res Ctr Resp Dis, Dept Resp & Crit Care Med, 87 Xiangya Rd, Changsha 410000, Hunan, Peoples R China 2.Huazhong Univ Sci & Technol, Ctr Biomed Res,Dept Resp & Crit Care Med, NHC Key Lab Pulm Dis,Key Cite Natl Clin Res Ctr, Wuhan Clin Med Res Ctr Chron Airway Dis,Tongji Ho, 1095 Jiefang Ave, Wuhan 430030, Peoples R China 3.Guilin Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp, 15 Lequn Rd, Guilin 541000, Guangxi, Peoples R China 4.Cent South Univ, Xiangya Hosp 2, ICU Div, Changsha 410011, Hunan, Peoples R China 5.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 6.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Gastroenterol & Hepatol, Wuhan 430030, Peoples R China
推荐引用方式 GB/T 7714	Rao, Li-Zong,Wang, Yi,Zhang, Lei,et al. IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages[J]. CELL DEATH AND DIFFERENTIATION,2021.
APA	Rao, Li-Zong.,Wang, Yi.,Zhang, Lei.,Wu, Guorao.,Zhang, Lu.,...&Zhang, Huilan.(2021).IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages.CELL DEATH AND DIFFERENTIATION.
MLA	Rao, Li-Zong,et al."IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages".CELL DEATH AND DIFFERENTIATION (2021).