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| Piezo1-Mediated Ca2+ Activities Regulate Brain Vascular Pathfinding during Development | |
| 2020-10-14 | |
| 发表期刊 | NEURON (IF:14.7[JCR-2023],16.9[5-Year]) |
| ISSN | 0896-6273 |
| 卷号 | 108期号:1页码:180-+ |
| 发表状态 | 已发表 |
| DOI | 10.1016/j.neuron.2020.07.025 |
| 摘要 | During development, endothelial tip cells (ETCs) located at the leading edge of growing vascular plexus guide angiogenic sprouts to target vessels, and thus, ETC pathfinding is fundamental for vascular pattern formation in organs, including the brain. However, mechanisms of ETC pathfinding remain largely unknown. Here, we report that Piezo1-mediated Ca2+ activities at primary branches of ETCs regulate branch dynamics to accomplish ETC pathfinding during zebrafish brain vascular development. ETC branches display spontaneous local Ca2+ transients, and high- and low-frequency Ca2+ transients cause branch retraction through calpain and branch extension through nitric oxide synthase, respectively. These Ca2+ transients are mainly mediated by Ca2+-permeable Piezo1 channels, which can be activated by mechanical force, and mutating piezo1 largely impairs ETC pathfinding and brain vascular patterning. These findings reveal that Piezo1 and down-stream Ca2+ signaling act as molecular bases for ETC pathfinding and highlight a novel function of Piezo1 and Ca2+ in vascular development. |
| 收录类别 | SCI ; SCIE |
| 语种 | 英语 |
| 资助项目 | Shanghai Municipal Science and Technology Major Project[18JC1410100][2018SHZDZX05] ; Key Research Program of Frontier Sciences[QYZDY-SSW-SMC028] ; Chinese Academy of Science[XDB32010200] |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| WOS记录号 | WOS:000579703400015 |
| 出版者 | CELL PRESS |
| 引用统计 | 正在获取...
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| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/123945 |
| 专题 | 生命科学与技术学院_博士生 生命科学与技术学院_特聘教授组_杜久林组 |
| 通讯作者 | Du, Jiu-lin |
| 作者单位 | 1.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai Res Ctr Brain Sci & Brain Inspired Intel, Inst Neurosci,State Key Lab Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, 19A Yu Quan Rd, Beijing 100049, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, 319 Yue Yang Rd, Shanghai 200031, Peoples R China |
| 通讯作者单位 | 生命科学与技术学院 |
| 推荐引用方式 GB/T 7714 | Liu, Ting-ting,Du, Xu-fei,Zhang, Bai-bing,et al. Piezo1-Mediated Ca2+ Activities Regulate Brain Vascular Pathfinding during Development[J]. NEURON,2020,108(1):180-+. |
| APA | Liu, Ting-ting.,Du, Xu-fei.,Zhang, Bai-bing.,Zi, Hua-xing.,Yan, Yong.,...&Du, Jiu-lin.(2020).Piezo1-Mediated Ca2+ Activities Regulate Brain Vascular Pathfinding during Development.NEURON,108(1),180-+. |
| MLA | Liu, Ting-ting,et al."Piezo1-Mediated Ca2+ Activities Regulate Brain Vascular Pathfinding during Development".NEURON 108.1(2020):180-+. |
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