The support of genetic evidence for cardiovascular risk induced by antineoplastic drugs
Cui, Hui1,2,3; Zuo, Shengkai3; Liu, Zipeng4; Liu, Huanhuan3; Wang, Jianhua3; You, Tianyi3; Zheng, Zhanye3; Zhou, Yao3; Qian, Xinyi3; Yao, Hongcheng4; Xie, Lu5; Liu, Tong6; Sham, Pak Chung4; Yu, Ying1,2,3; Li, Mulin Jun3,7
2020-10
Source PublicationSCIENCE ADVANCES
ISSN2375-2548
Volume6Issue:42
Status已发表
DOI10.1126/sciadv.abb8543
AbstractCardiovascular dysfunction is one of the most common complications of long-term cancer treatment. Growing evidence has shown that antineoplastic drugs can increase cardiovascular risk during cancer therapy, seriously affecting patient survival. However, little is known about the genetic factors associated with the cardiovascular risk of antineoplastic drugs. We established a compendium of genetic evidence that supports cardiovascular risk induced by antineoplastic drugs. Most of this genetic evidence is attributed to causal alleles altering the expression of cardiovascular disease genes. We found that antineoplastic drugs predicted to induce cardiovascular risk are significantly enriched in drugs associated with cardiovascular adverse reactions, including many first-line cancer treatments. Functional experiments validated that retinoid X receptor agonists can reduce triglyceride lipolysis, thus modulating cardiovascular risk. Our results establish a link between the causal allele of cardiovascular disease genes and the direction of pharmacological modulation, which could facilitate cancer drug discovery and clinical trial design.
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Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31871327][81790623][81525004][31800995] ; Chinese Ministry of Science and Technology[2017YFC1307404] ; Tianjin Committee of Science and Technology[19JCJQJC63600][18JCZDJC34700][17JCYBJC40700] ; China Postdoctoral Science Foundation[2018M640242] ; National Postdoctoral Program for Innovative Talents[BX20180215]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000579164600020
PublisherAMER ASSOC ADVANCEMENT SCIENCE
Citation statistics
Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/123942
Collection信息科学与技术学院_本科生
生命科学与技术学院_特聘教授组_余鹰组
附属学校、幼儿园筹建部
生命科学与技术学院_博士生
Corresponding AuthorYu, Ying; Li, Mulin Jun
Affiliation1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
2.Chinese Acad Sci, Univ Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Bio, Key Lab Food Safety Res,Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China
3.Tianjin Med Univ, Sch Basic Med Sci, Dept Pharmacol, Tianjin Key Lab Inflammat Biol, Tianjin, Peoples R China
4.Univ Hong Kong, LKS Fac Med, Ctr Panor Sci Genom & Bioinformat Cores, Hong Kong, Peoples R China
5.Shanghai Acad Sci & Technol, Shanghai Ctr Bioinformat Technol, Shanghai, Peoples R China
6.Tianjin Med Univ, Tianjin Inst Cardiol, Dept Cardiol, Tianjin Key Lab Ion Mol Funct Cardiovasc Dis,Hosp, Tianjin, Peoples R China
7.Tianjin Med Univ, Tianjin Med Univ Canc Inst & Hosp, Natl Clin Res Ctr Canc, Dept Epidemiol & Biostat,Tianjin Key Lab Mol Canc, Tianjin, Peoples R China
First Author AffilicationSchool of Life Science and Technology
Corresponding Author AffilicationSchool of Life Science and Technology
First Signature AffilicationSchool of Life Science and Technology
Recommended Citation
GB/T 7714
Cui, Hui,Zuo, Shengkai,Liu, Zipeng,et al. The support of genetic evidence for cardiovascular risk induced by antineoplastic drugs[J]. SCIENCE ADVANCES,2020,6(42).
APA Cui, Hui.,Zuo, Shengkai.,Liu, Zipeng.,Liu, Huanhuan.,Wang, Jianhua.,...&Li, Mulin Jun.(2020).The support of genetic evidence for cardiovascular risk induced by antineoplastic drugs.SCIENCE ADVANCES,6(42).
MLA Cui, Hui,et al."The support of genetic evidence for cardiovascular risk induced by antineoplastic drugs".SCIENCE ADVANCES 6.42(2020).
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