Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis in vivo

doi:10.1111/cas.14601

	Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis in vivo
	Wang, Xingshun 1,2; Feng, Weimin 1; Peng, Cheng 1,2; Chen, Shiyun 1; Ji, Hongbin3,4,5,6 ; Zhong, Hanbing 1; Ge, Wei 2; Zhang, Yandong 1,7
	2020-10
发表期刊	CANCER SCIENCE (IF:4.5[JCR-2023],5.5[5-Year])
ISSN	1347-9032
EISSN	1349-7006
发表状态	已发表
DOI	10.1111/cas.14601
摘要	Ras has been found to be mutated in 30% of non-small cell lung cancers, and its mutation has been regarded as a causal factor underlying tumorigenesis. However, no successful medicine has been developed so far to inhibit Ras for lung cancer treatment. We have previously identified DHX33 as a Ras downstream effector, promoting cell cycle progression and cell growth. In this study, with the K-Ras (G12D);DHX33 (lox/lox) mouse model, we discovered that genetic ablation of DHX33 inhibited tumor development. We further found that ablation of DHX33 altered the expression of nearly 2000 genes which are critical in cancer development such as cell cycle, apoptosis, glycolysis, Wnt signaling, and cell migration. Our study for the first time demonstrates the pivotal role of the DHX33 in Ras-driven lung cancer development in vivo and highlights that pharmacological targeting DHX33 can be a feasible option in treating Ras-mutant lung cancers.
关键词	DHX33 lung cancer oncogene Ras RNA helicase
收录类别	SCI ; SCIE
语种	英语
资助项目	Shenzhen Science and Technology Innovation Commission[CKCY20170721164627271]
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000562037800001
出版者	WILEY
WOS关键词	TRANSLATION
原始文献类型	Article ; Early Access
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/123060
专题	生命科学与技术学院_特聘教授组_季红斌组
通讯作者	Zhang, Yandong
作者单位	1.Southern Univ Sci & Technol, Dept Biol, Shenzhen, Peoples R China 2.Univ Macau, Fac Hlth Sci, Macau, Peoples R China 3.State Key Lab Cell Biol, Shanghai, Peoples R China 4.CAS Ctr Excellence Mol Cell Sci, Shanghai, Peoples R China 5.Chinese Acad Sci, Innovat Ctr Cell Signaling Network, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China 6.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 7.KeYe Life Technol Co Ltd, Room 203,Bldg 1,Block B, Shenzhen, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xingshun,Feng, Weimin,Peng, Cheng,et al. Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis in vivo[J]. CANCER SCIENCE,2020.
APA	Wang, Xingshun.,Feng, Weimin.,Peng, Cheng.,Chen, Shiyun.,Ji, Hongbin.,...&Zhang, Yandong.(2020).Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis in vivo.CANCER SCIENCE.
MLA	Wang, Xingshun,et al."Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis in vivo".CANCER SCIENCE (2020).