Parabrachial neuron types categorically encode thermoregulation variables during heat defense
2020-09
发表期刊SCIENCE ADVANCES (IF:11.7[JCR-2023],13.7[5-Year])
ISSN2375-2548
卷号6期号:36
DOI10.1126/sciadv.abb9414
摘要Heat defense is crucial for survival and fitness. Transmission of thermosensory signals into hypothalamic thermoregulation centers represents a key layer of regulation in heat defense. Yet, how these signals are transmitted into the hypothalamus remains poorly understood. Here, we reveal that lateral parabrachial nucleus (LPB) glutamatergic prodynorphin and cholecystokinin neuron populations are progressively recruited to defend elevated body temperature. These two nonoverlapping neuron types form circuits with downstream preoptic hypothalamic neurons to inhibit the thermogenesis of brown adipose tissues (BATs) and activate tail vasodilation, respectively. Both circuits are activated by warmth and can limit fever development. The prodynorphin circuit is further required for regulating energy expenditure and body weight homeostasis. Thus, these findings establish that the genetic and functional specificity of heat defense neurons occurs as early as in the LPB and uncover categorical neuron types for encoding two heat defense variables, inhibition of BAT thermogenesis and activation of vasodilation.
收录类别SCI ; SCIE ; EI
语种英语
资助项目National Key Research and Development Program of China[2019YFA0801900] ; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions[NYKFKT20190017] ; National Nature Science Foundation of China[31771169][91857104] ; Shanghai Science and Technology Committee of Shanghai City[19140903800]
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000567766700031
出版者AMER ASSOC ADVANCEMENT SCIENCE
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文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/122983
专题免疫化学研究所_PI研究组_杨海涛组
生命科学与技术学院_PI研究组_沈伟组
生命科学与技术学院_硕士生
生命科学与技术学院_博士生
生命科学与技术学院_本科生
共同第一作者Xiaosa Du; Wen Zhang; Cuicui Gao
通讯作者Wen Z. Yang; Wei L. Shen
作者单位
1.Shanghai Institute for Advanced Immunochemical Studies, Shanghaitech University, Shanghai 201210, China
2.School of Life Science and Technology, Shanghaitech University, Shanghai 201210, China
3.CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
4.Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
5.University of Chinese Academy of Sciences, Beijing 100049, China.
6.Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China.
7.Department of Neurology, Shanghai Sixth People’s Hospital East Affiliated to Shanghai University of Medicine and Health Science, 222 West Third Road, Huanhu, Shanghai 201306, China.
8.Thermoregulation and Inflammation Laboratory, Chengdu Medical College, Chengdu Sichuan 610500, China.
9.Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China.
10.Shenzhen Key Laboratory of Drug Addiction, CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China.
第一作者单位免疫化学研究所;  生命科学与技术学院
通讯作者单位免疫化学研究所;  生命科学与技术学院
第一作者的第一单位免疫化学研究所
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GB/T 7714
Wen Z. Yang,Xiaosa Du,Wen Zhang,et al. Parabrachial neuron types categorically encode thermoregulation variables during heat defense[J]. SCIENCE ADVANCES,2020,6(36).
APA Wen Z. Yang.,Xiaosa Du.,Wen Zhang.,Cuicui Gao.,Hengchang Xie.,...&Wei L. Shen.(2020).Parabrachial neuron types categorically encode thermoregulation variables during heat defense.SCIENCE ADVANCES,6(36).
MLA Wen Z. Yang,et al."Parabrachial neuron types categorically encode thermoregulation variables during heat defense".SCIENCE ADVANCES 6.36(2020).
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