Association of Rare PTGIS Variants With Susceptibility and Pulmonary Vascular Response in Patients With Idiopathic Pulmonary Arterial Hypertension

doi:10.1001/jamacardio.2020.0479

KMS > 免疫化学研究所 > 特聘教授组 > Roger D. Kornberg组

	Association of Rare PTGIS Variants With Susceptibility and Pulmonary Vascular Response in Patients With Idiopathic Pulmonary Arterial Hypertension
	Wang, Xiao-Jian 1; Xu, Xi-Qi 1,2; Sun, Kai 1,2; Liu, Ke-Qiang 3; Li, Su-Qi 1; Jiang, Xin 1,2; Zhao, Qin-Hua 4; Wang, Lan 4; Peng, Fu-Hua 1; Ye, Jue 1; Wu, Yan 1; Jiang, Rui 5; Zhang, Jin 6; Huang, Wei 7; Wei, Wen-Bin 8; Yan, Yi 1; Li, Jing-Hui 1; Liu, Qian-Qian 1; Li, Sheng9 ; Wang, Yong 10; Zhang, Shu-Yang 2; Zhang, Xue 3; Jing, Zhi-Cheng 2
	2020-06
发表期刊	JAMA CARDIOLOGY (IF:14.8[JCR-2023],16.0[5-Year])
ISSN	2380-6583
EISSN	2380-6591
卷号	5 期号:6 页码:677-684
发表状态	已发表
DOI	10.1001/jamacardio.2020.0479
摘要	Question What is the novel susceptibility gene for idiopathic pulmonary arterial hypertension? Findings In this 2-stage genetic association study of 230 patients with idiopathic pulmonary arterial hypertension, heterozygous rare PTGIS variants were first found significantly overrepresented in 6.1%, conferring 7.8 higher odds of pulmonary arterial hypertension. In addition, patients carrying rare PTGIS variants were more responsive to iloprost stimulation than those without such variants. Meaning The rare variants of the PTGIS gene appear to contribute higher susceptibility to idiopathic pulmonary arterial hypertension, and screening of PTGIS variants may help improve personalized treatment of these patients.
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
资助项目	Beijing Natural Science Foundation[7181009][7172180] ; National Key Research and Development Program of China[2016YFC0901502] ; National Natural Science Foundation of China[81630003][81670052][81870050] ; Drug Innovation Major Project[2018ZX09711001-003-012] ; Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences[2016-I2M-1-002][2016-I2M-4-003][2017-I2M-3-003][2017-I2M-1-004][2017-I2M-2-001] ; CAMS Fund for Key Laboratory of Pulmonary Vascular Medicine[2017PT32016] ; CAMS Fund for Young Talents of Medical Science[2018RC310007] ; Sanming Project of Medicine in Shenzhen[SZSM201502001]
WOS研究方向	Cardiovascular System & Cardiology
WOS类目	Cardiac & Cardiovascular Systems
WOS记录号	WOS:000545603400011
出版者	AMER MEDICAL ASSOC
WOS关键词	PROSTACYCLIN SYNTHASE ; SURVIVAL ; THROMBOXANE ; EXPRESSION ; MUTATIONS ; DIAGNOSIS ; RECEPTOR ; BMPR2
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/122453
专题	免疫化学研究所_特聘教授组_结构生物化学实验室
通讯作者	Zhang, Xue; Jing, Zhi-Cheng
作者单位	1.Chinese Acad Med Sci & Peking Union Med Coll, FuWai Hosp, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis, Beijing, Peoples R China 2.Chinese Acad Med Sci & Peking Union Med Coll Hosp, Dept Cardiol, Peking Union Med Coll Hosp, Beijing, Peoples R China 3.Chinese Acad Med Sci, Peking Union Med Coll, Inst Basic Med Sci, McKusick Zhang Ctr Genet Med,State Key Lab Med Me, 9 Dongdansantiao, Beijing 100730, Peoples R China 4.Tongji Univ, Sch Med, Dept Cardiopulm Circulat, Shanghai Pulm Hosp, Shanghai, Peoples R China 5.Tsinghua Univ, Minist Educ MOE, Dept Automat,Key Lab Bioinformat, Bioinformat Div,Beijing Natl Res Ctr Informat Sci, Beijing, Peoples R China 6.Xi An Jiao Tong Univ, Sch Basic Med Sci, Cardiovasc Res Ctr, Xian, Peoples R China 7.Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, Chongqing, Peoples R China 8.Sun Yat Sen Univ, Cardiovasc Ctr, Affiliated Hosp 8, Shenzhen, Peoples R China 9.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai, Peoples R China 10.Capital Med Univ, Beijing Shijitan Hosp, Dept Resp Med, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xiao-Jian,Xu, Xi-Qi,Sun, Kai,et al. Association of Rare PTGIS Variants With Susceptibility and Pulmonary Vascular Response in Patients With Idiopathic Pulmonary Arterial Hypertension[J]. JAMA CARDIOLOGY,2020,5(6):677-684.
APA	Wang, Xiao-Jian.,Xu, Xi-Qi.,Sun, Kai.,Liu, Ke-Qiang.,Li, Su-Qi.,...&Jing, Zhi-Cheng.(2020).Association of Rare PTGIS Variants With Susceptibility and Pulmonary Vascular Response in Patients With Idiopathic Pulmonary Arterial Hypertension.JAMA CARDIOLOGY,5(6),677-684.
MLA	Wang, Xiao-Jian,et al."Association of Rare PTGIS Variants With Susceptibility and Pulmonary Vascular Response in Patients With Idiopathic Pulmonary Arterial Hypertension".JAMA CARDIOLOGY 5.6(2020):677-684.