GTDB: an integrated resource for glycosyltransferase sequences and annotations

doi:10.1093/database/baaa047

	GTDB: an integrated resource for glycosyltransferase sequences and annotations
	Zhou, Chenfen 1; Xu, Qingwei 2; He, Sheng1,3 ; Ye, Wei 1; Cao, Ruifang 1; Wang, Pengyu 1; Ling, Yunchao 1; Yan, Xing 4; Wang, Qingzhong 1; Zhang, Guoqing 1
	2020-06-16
发表期刊	DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (IF:3.4[JCR-2023],4.2[5-Year])
ISSN	1758-0463
发表状态	已发表
DOI	10.1093/database/baaa047
摘要	Glycosyltransferases (GTs), a large class of carbohydrate-active enzymes, adds glycosyl moieties to various substrates to generate multiple bioactive compounds, including natural products with pharmaceutical or agrochemical values. Here, we first collected comprehensive information on GTs, including amino acid sequences, coding region sequences, available tertiary structures, protein classification families, catalytic reactions and metabolic pathways. Then, we developed sequence search and molecular docking processes for GTs, resulting in a GTs database (GTDB). In the present study, 520 179 GTs from approximately 21 647 species that involved in 394 kinds of different reactions were deposited in GTDB. GTDB has the following useful features: (i) text search is provided for retrieving the complete details of a query by combining multiple identifiers and data sources; (ii) a convenient browser allows users to browse data by different classifications and download data in batches; (iii) BLAST is offered for searching against pre-defined sequences, which can facilitate the annotation of the biological functions of query GTs; and lastly, (iv) GTdock using AutoDock Vina performs docking simulations of several GTs with the same single acceptor and displays the results based on 3Dmol.js allowing easy view of models.
收录类别	SCI ; SCIE
语种	英语
资助项目	National Key Research and Development Program of China[2018YFA0900704][2017YFC1201200] ; International Partnership Program of Chinese Academy of Sciences[153D31KYSB20170121] ; Key Research Program of the Chinese Academy of Sciences[KFZD-SW-219-5] ; Zhangjiang special project of national innovation demonstration zone[ZJ2018-ZD-013] ; National Natural Science Foundation of China[31871281] ; Science and Technology Service Network Initiative of Chinese Academy of Sciences[Y919C11011]
WOS研究方向	Mathematical & Computational Biology
WOS类目	Mathematical & Computational Biology
WOS记录号	WOS:000545999100001
出版者	OXFORD UNIV PRESS
WOS关键词	DATABASE ; IDENTIFICATION ; BIOSYNTHESIS
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/122442
专题	生命科学与技术学院_博士生
通讯作者	Zhang, Guoqing
作者单位	1.Chinese Acad Sci, Univ Chinese Acad Sci, CAS MPG Partner Inst Computat Biol,Natl Genom Dat, Shanghai Inst Nutr & Hlth,Biomed Big Data Ctr,Key, 320 Yueyang Rd, Shanghai 200031, Peoples R China 2.Hubei Univ Educ, Coll Comp, 129 Second Gaoxin Rd, Wuhan 430205, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China 4.Chinese Acad Sci, Inst Plant Physiol & Ecol, CAS Ctr Excellence Mol Plant Sci, CAS Key Lab Synthet Biol, 300 Fenglin Rd, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Chenfen,Xu, Qingwei,He, Sheng,et al. GTDB: an integrated resource for glycosyltransferase sequences and annotations[J]. DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION,2020.
APA	Zhou, Chenfen.,Xu, Qingwei.,He, Sheng.,Ye, Wei.,Cao, Ruifang.,...&Zhang, Guoqing.(2020).GTDB: an integrated resource for glycosyltransferase sequences and annotations.DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.
MLA	Zhou, Chenfen,et al."GTDB: an integrated resource for glycosyltransferase sequences and annotations".DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2020).