GABA(B) receptor pas de deux: insights from high-resolution structures

doi:10.1038/s41422-020-0373-y

	GABA(B) receptor pas de deux: insights from high-resolution structures
	Jiang, Yi 1,2; Xu, H. Eric1,2,3
	2020-08
发表期刊	CELL RESEARCH
ISSN	1001-0602
EISSN	1748-7838
发表状态	已发表
DOI	10.1038/s41422-020-0373-y
摘要	The GABA(B) receptors are heterodimeric class C G protein-coupled receptors (GPCRs) that mediate the inhibitory neurotransmission in the central nervous system and they are drug targets for alcoholism and pain control. In a recent paper published in Cell Research, Mao et al. reported the first full-length GABA(B) heterodimer structures in both inactive and active states, providing a framework for understanding the activation of class C GPCRs and a template for designing allosteric modulators targeting the dimeric interface of the GABA(B) receptors.
URL	查看原文
收录类别	SCI ; SCIE
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000547232900001
出版者	NATURE PUBLISHING GROUP
原始文献类型	Editorial Material
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/122433
专题	生命科学与技术学院_特聘教授组_徐华强组
通讯作者	Jiang, Yi; Xu, H. Eric
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Jiang, Yi,Xu, H. Eric. GABA(B) receptor pas de deux: insights from high-resolution structures[J]. CELL RESEARCH,2020.
APA	Jiang, Yi,&Xu, H. Eric.(2020).GABA(B) receptor pas de deux: insights from high-resolution structures.CELL RESEARCH.
MLA	Jiang, Yi,et al."GABA(B) receptor pas de deux: insights from high-resolution structures".CELL RESEARCH (2020).