Analysis on gene modular network reveals morphogen-directed development robustness inDrosophila

doi:10.1038/s41421-020-0173-z

	Analysis on gene modular network reveals morphogen-directed development robustness inDrosophila
	Zhang, Shuo 1,2; Zhao, Juan 1,3; Lv, Xiangdong 1,2; Fan, Jialin 1,2; Lu, Yi 1; Zeng, Tao 1,3; Wu, Hailong 1; Chen, Luonan1,3,4,5 ; Zhao, Yun1,4,6
	2020-06-30
发表期刊	CELL DISCOVERY (IF:13.0[JCR-2023],14.8[5-Year])
EISSN	2056-5968
卷号	6 期号:1
发表状态	已发表
DOI	10.1038/s41421-020-0173-z
摘要	Genetic robustness is an important characteristic to tolerate genetic or nongenetic perturbations and ensure phenotypic stability. Morphogens, a type of evolutionarily conserved diffusible molecules, govern tissue patterns in a direction-dependent or concentration-dependent manner by differentially regulating downstream gene expression. However, whether the morphogen-directed gene regulatory network possesses genetic robustness remains elusive. In the present study, we collected 4217 morphogen-responsive genes along A-P axis ofDrosophilawing discs from the RNA-seq data, and clustered them into 12 modules. By applying mathematical model to the measured data, we constructed a gene modular network (GMN) to decipher the module regulatory interactions and robustness in morphogen-directed development. The computational analyses on asymptotical dynamics of this GMN demonstrated that this morphogen-directed GMN is robust to tolerate a majority of genetic perturbations, which has been further validated by biological experiments. Furthermore, besides the genetic alterations, we further demonstrated that this morphogen-directed GMN can well tolerate nongenetic perturbations (Hh production changes) via computational analyses and experimental validation. Therefore, these findings clearly indicate that the morphogen-directed GMN is robust in response to perturbations and is important forDrosophilato ensure the proper tissue patterning in wing disc.
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收录类别	SCI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China[31630047][31671453][31771476] ; National Key R&D Program of China[2017YFA0503600][2017YFA0505500] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB19020100] ; Program of Shanghai Academic/Technology Research Leader[17XD1404100] ; International Partnership Program of the Chinese Academy of Sciences[153D31KYSB20160137]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000546187700001
出版者	NATURE PUBLISHING GROUP
WOS关键词	REGULATORY NETWORK ; HEDGEHOG ; DIFFERENTIATION ; GENERATION ; POSITION ; MODELS
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/122430
专题	生命科学与技术学院_特聘教授组_陈洛南组生命科学与技术学院_特聘教授组_赵允组
通讯作者	Chen, Luonan; Zhao, Yun
作者单位	1.Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol,Chinese Acad Sci, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, CAS Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 5.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Chinese Acad Sci, Key Lab Syst Biol, Hangzhou 310024, Zhejiang, Peoples R China 6.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Hangzhou 310024, Zhejiang, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zhang, Shuo,Zhao, Juan,Lv, Xiangdong,et al. Analysis on gene modular network reveals morphogen-directed development robustness inDrosophila[J]. CELL DISCOVERY,2020,6(1).
APA	Zhang, Shuo.,Zhao, Juan.,Lv, Xiangdong.,Fan, Jialin.,Lu, Yi.,...&Zhao, Yun.(2020).Analysis on gene modular network reveals morphogen-directed development robustness inDrosophila.CELL DISCOVERY,6(1).
MLA	Zhang, Shuo,et al."Analysis on gene modular network reveals morphogen-directed development robustness inDrosophila".CELL DISCOVERY 6.1(2020).