ShanghaiTech University Knowledge Management System
| PolyA-based DNA bonds with programmable bond length and bond energy | |
| 2020-07-03 | |
| Source Publication | NPG ASIA MATERIALS
 |
| ISSN | 1884-4049 |
| EISSN | 1884-4057 |
| Volume | 12Issue:1 |
| Status | 已发表 |
| DOI | 10.1038/s41427-020-0231-x |
| Abstract | DNA-functionalized Au nanoparticles (AuNPs) have been intensively exploited as programmable atom equivalents (PAEs) for the self-assembly of molecule-like structures. However, it remains challenging to build hierarchical PAE assemblies via discrete DNA bonds at different levels. Here, we report a strategy to program DNA bond length and bond energy on PAEs using DNA encoders carrying consecutive adenines (polyA). On AuNPs, we built three types of DNA motifs with different topologic configurations, which can form bonds for PAE self-assembly. By small-angle X-ray scattering (SAXS) analysis, we found that the bond length and flexibility between the coupled PAEs can be tuned by programming the bond structure. We also found that these bonds show different bond energies and thus differ, depending on their topologic configuration, leading to different PAE assembly efficiencies. We demonstrated that the bonds at different levels can be arranged in different directions on one nanoparticle, leading to asymmetric PAEs that allow ionic strength-controlled hierarchical assembly of multiparticle structures. This programmable bonding system may provide a new route for building complex plasmonic superstructures. |
| URL | 查看原文 |
| Indexed By | SCI ; SCIE ; EI |
| Language | 英语 |
| Funding Project | National Key R&D Program of China[2016YFA0201200] ; National Natural Science Foundation of China[21834007][21675167][31571014][21775157][11575278] ; Shanghai Municipal Science and Technology Commission[19JC1410302] |
| WOS Research Area | Materials Science |
| WOS Subject | Materials Science, Multidisciplinary |
| WOS ID | WOS:000544962400001 |
| Publisher | NATURE PUBLISHING GROUP |
| WOS Keyword | NUCLEOSOME CORE PARTICLE ; NANOPARTICLE SUPERLATTICES ; CRYSTAL-STRUCTURE ; NANOSTRUCTURES ; FUNCTIONALIZATION ; OLIGONUCLEOTIDE ; ASSEMBLIES ; ORDER |
| Original Document Type | Article |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/121915 |
| Collection | 生命科学与技术学院_硕士生 |
| Corresponding Author | Li, Jiang |
| Affiliation | 1.Chinese Acad Sci, Div Phys Biol, CAS Key Lab Interfacial Phys & Technol, Shanghai Inst Appl Phys,Univ Chinese Acad Sci, Shanghai 201800, Peoples R China 2.Shanghai Jiao Tong Univ, Frontiers Sci Ctr Transformat Mol, Sch Chem & Chem Engn, Inst Mol Med,Renji Hosp,Sch Med, Shanghai 200240, Peoples R China 3.Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China |
| Recommended Citation GB/T 7714 | Chen, Xiaoliang,Liu, Xiaoguo,Yao, Guangbao,et al. PolyA-based DNA bonds with programmable bond length and bond energy[J]. NPG ASIA MATERIALS,2020,12(1). |
| APA | Chen, Xiaoliang.,Liu, Xiaoguo.,Yao, Guangbao.,Li, Qian.,Liu, Renduo.,...&Li, Jiang.(2020).PolyA-based DNA bonds with programmable bond length and bond energy.NPG ASIA MATERIALS,12(1). |
| MLA | Chen, Xiaoliang,et al."PolyA-based DNA bonds with programmable bond length and bond energy".NPG ASIA MATERIALS 12.1(2020). |
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