The Effects of Graded Levels of Calorie Restriction XV: Phase Space Attractors Reveal Distinct Behavioral Phenotypes

doi:10.1093/gerona/glaa055

	The Effects of Graded Levels of Calorie Restriction XV: Phase Space Attractors Reveal Distinct Behavioral Phenotypes
	Sun, Deshun 1,2; Liu, Fei 1; Mitchell, Sharon E.3; Ma, Huanfei 4; Derous, Davina 3; Wang, Yingchun 5; Han, Jackie J. D.6; Promislow, Daniel E. L.7,8; Lusseau, David 3; Douglas, Alex 3; Speakman, John R.3,5,11; Chen, Luonan9,10,11
	2020-05
发表期刊	JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (IF:4.3[JCR-2023],5.0[5-Year])
ISSN	1079-5006
EISSN	1758-535X
卷号	75 期号:5 页码:858-866
发表状态	已发表
DOI	10.1093/gerona/glaa055
摘要	Calorie restriction (CR) has a positive impact on health and life span. Previous work, however, does not reveal the whole underlying mechanism of behavioral phenotypes under CR. We propose a new approach based on phase space reconstruction (PSR) to analyze the behavioral responses of mice to graded CR. This involved reconstructing high-dimensional attractors which topologically represent the intrinsic dynamics of mice based on low-dimensional time series of movement counts observed during the 90-day time course of restriction. PSR together with correlation dimensions (CD), Kolmogorov entropy (KE), and multifractal spectra builds a map from internal attractors to the phenotype of mice and reveals the mice with increasing CR levels undergo significant changes from a normal to a new state. Features of the attractors (CD and KE) were significantly associated with gene expression profiles in the hypothalamus of the same individuals.
关键词	Calorie restriction Phase space reconstruction Attractors Gene expression
收录类别	SCI ; SCIE ; SSCI
语种	英语
资助项目	National Key Research and Development (R&D) Program of China[2017YFA0505500] ; National Natural Science Foundation of China[61873094][31930022][31771476][81471047][91649108][11771010] ; Natural Science Foundation of Guangdong Province of China[2018A030313338] ; Shanghai Municipal Science and Technology Major Project[2017SHZDZX01] ; Science and Technology Program of Guangzhou, China[201804010246] ; Pre-Research Foundation of China[61400010205] ; UK Biotechnology and Biological Sciences Research Council (BBSRC)[BB/G009953/1] ; China partnering award[BBSRC BB/J020028/1]
WOS研究方向	Geriatrics & Gerontology
WOS类目	Geriatrics & Gerontology ; Gerontology
WOS记录号	WOS:000537440900006
出版者	OXFORD UNIV PRESS INC
WOS关键词	SHORT-TERM CALORIE ; PROTEIN RESTRICTION ; TRANSCRIPTOMIC RESPONSES ; KOLMOGOROV-ENTROPY ; PHYSICAL-ACTIVITY ; BODY-TEMPERATURE ; TIME-SERIES ; IMPACT ; LIFE ; MORTALITY
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/121631
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_陈洛南组
通讯作者	Liu, Fei
作者单位	1.South China Univ Technol, Sch Software Engn, Guangzhou 510006, Peoples R China 2.Shenzhen Univ, Shenzhen Key Lab Tissue Engn, Shenzhen Peoples Hosp 2,Affiliated Hosp 1, Hlth Sci Ctr,Shenzhen Lab Digital Orthoped Engn, Shenzhen, Peoples R China 3.Univ Aberdeen, Inst Biol & Environm Sci, Aberdeen, Scotland 4.Soochow Univ, Sch Math Sci, Suzhou, Peoples R China 5.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Computat Biol, Chinese Acad Sci Max Planck Partner Inst Computat, Shanghai, Peoples R China 7.Univ Washington, Dept Pathol, Seattle, WA 98195 USA 8.Univ Washington, Dept Biol, Seattle, WA 98195 USA 9.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol,Ctr Excellence Mol Cell Sci, Shanghai, Peoples R China 10.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 11.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Sun, Deshun,Liu, Fei,Mitchell, Sharon E.,et al. The Effects of Graded Levels of Calorie Restriction XV: Phase Space Attractors Reveal Distinct Behavioral Phenotypes[J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,2020,75(5):858-866.
APA	Sun, Deshun.,Liu, Fei.,Mitchell, Sharon E..,Ma, Huanfei.,Derous, Davina.,...&Chen, Luonan.(2020).The Effects of Graded Levels of Calorie Restriction XV: Phase Space Attractors Reveal Distinct Behavioral Phenotypes.JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,75(5),858-866.
MLA	Sun, Deshun,et al."The Effects of Graded Levels of Calorie Restriction XV: Phase Space Attractors Reveal Distinct Behavioral Phenotypes".JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 75.5(2020):858-866.