Dexmedetomidine activation of dopamine neurons in the ventral tegmental area attenuates the depth of sedation in mice

doi:https://doi.org/10.1097/ALN.0000000000003347

	Dexmedetomidine activation of dopamine neurons in the ventral tegmental area attenuates the depth of sedation in mice
	Qiu, Gaolin 1; Wu, Ying 1; Yang, Zeyong 5; Li, Long 3; Zhu, Xiaona2 ; Wang, Yiqiao 6; Sun, Wenzhi 4; Dong, Hailong 3; Li, Yuanhai 1; Hu, Ji2,7
	2020-05-12
发表期刊	ANESTHESIOLOGY (IF:9.1[JCR-2023],8.5[5-Year])
ISSN	0003-3022
EISSN	1528-1175
卷号	133 期号:2 页码:377-392
发表状态	已发表
DOI	https://doi.org/10.1097/ALN.0000000000003347
摘要	Background: Dexmedetomidine induces a sedative response that is associated with rapid arousal. To elucidate the underlying mechanisms, the authors hypothesized that dexmedetomidine increases the activity of dopaminergic neurons in the ventral tegmental area, and that this action contributes to the unique sedative properties of dexmedetomidine.
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收录类别	ESCI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China (Beijing, China)[31922029][31671086][61890951][61890950][81701049]
WOS研究方向	Anesthesiology
WOS类目	Anesthesiology
WOS记录号	WOS:000562777500016
出版者	LIPPINCOTT WILLIAMS & WILKINS
WOS关键词	IN-VIVO REGULATION ; GENERAL-ANESTHESIA ; EXTRACELLULAR DOPAMINE ; NORADRENALINE RELEASE ; SLEEP ; EMERGENCE ; RAT ; MICRODIALYSIS ; REANIMATION ; DECREASES
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/121244
专题	生命科学与技术学院_PI研究组_胡霁组
共同第一作者	Wu, Ying
通讯作者	Hu, Ji
作者单位	1.Anhui Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Hefei, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Fourth Mil Med Univ, Dept Anesthesiol & Perioperat Med, Xijing Hosp, Xian, Shanxi, Peoples R China 4.Chinese Inst Brain Res, Beijing, Peoples R China 5.Shanghai Jiao Tong Univ, Sch Med, Dept Anesthesiol, Int Peace Matern & Child Hlth Hosp, Shanghai, Peoples R China 6.Anhui 2 Prov Peoples Hosp, Dept Anesthesiol, Hefei, Anhui, Peoples R China 7.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Qiu, Gaolin,Wu, Ying,Yang, Zeyong,et al. Dexmedetomidine activation of dopamine neurons in the ventral tegmental area attenuates the depth of sedation in mice[J]. ANESTHESIOLOGY,2020,133(2):377-392.
APA	Qiu, Gaolin.,Wu, Ying.,Yang, Zeyong.,Li, Long.,Zhu, Xiaona.,...&Hu, Ji.(2020).Dexmedetomidine activation of dopamine neurons in the ventral tegmental area attenuates the depth of sedation in mice.ANESTHESIOLOGY,133(2),377-392.
MLA	Qiu, Gaolin,et al."Dexmedetomidine activation of dopamine neurons in the ventral tegmental area attenuates the depth of sedation in mice".ANESTHESIOLOGY 133.2(2020):377-392.