SMAD7 and SERPINE1 as novel dynamic network biomarkers detect and regulate the tipping point of TGF-beta induced EMT

doi:10.1016/j.scib.2020.01.013

	SMAD7 and SERPINE1 as novel dynamic network biomarkers detect and regulate the tipping point of TGF-beta induced EMT
	Jiang, Zhonglin 1; Lu, Lina 1; Liu, Yuwei 3,4,8; Zhang, Si1,6 ; Li, Shuxian1,6 ; Wang, Guanyu 7; Wang, Peng2,6 ; Chen, Luonan1,5,6
	2020-05-30
发表期刊	SCIENCE BULLETIN (IF:18.8[JCR-2023],15.8[5-Year])
ISSN	2095-9273
EISSN	2095-9281
卷号	65 期号:10 页码:842-853
发表状态	已发表
DOI	10.1016/j.scib.2020.01.013
摘要	Epithelial-mesenchymal transition (EMT) is a complex nonlinear biological process that plays essential roles in fundamental biological processes such as embryogenesis, wounding healing, tissue regeneration, and cancer metastasis. A hallmark of EMT is the switch-like behavior during state transition, which is characteristic of phase transitions. Hence, detecting the tipping point just before mesenchymal state transition is critical for understanding molecular mechanism of EMT. Through dynamic network biomarkers (DNB) model, a DNB group with 37 genes was identified which can provide the early-warning signals of EMT. Particularly, we found that two DNB genes, i.e., SMAD7 and SERPINE1 promoted EMT by switching their regulatory network which was further validated by biological experiments. Survival analyses revealed that SMAD7 and SERPINE1 as DNB genes further acted as prognostic biomarkers for lung adenocarcinoma. (C) 2020 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved.
关键词	Dynamic network biomarker Tipping point Epithelial-mesenchymal transition Bistability Quantitative real-time PCR
收录类别	SCI ; SCIE ; EI
语种	英语
资助项目	National Key Research and Development Program of China[2017YFA0505500] ; National Natural Science Foundation of China[31930022][31771476][61773196] ; Shanghai Municipal Science and Technology Major Project[2017SHZDZX01] ; Key Project of Zhangjiang National Innovation Demonstration Zone Special Development Fund[ZJ2018ZD-013] ; Ministry of Science and Technology Project[2017YFC0907505] ; Guangdong Provincial Key Laboratory Funds[2017B030301018][2019B030301001] ; Shenzhen Research Funds[JCYJ20170307104535585][ZDSYS20140509142721429] ; Shenzhen Peacock Plan[KQTD2016053117035204]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000531830800013
出版者	ELSEVIER
WOS关键词	EPITHELIAL-MESENCHYMAL TRANSITION ; GROWTH-FACTOR-BETA ; FEEDBACK LOOP ; EXPRESSION ; SURVIVAL ; BREAST ; TRANSDIFFERENTIATION ; PROLIFERATION ; ACTIVATION ; MECHANISMS
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120970
专题	生命科学与技术学院_博士生生命科学与技术学院_特聘教授组_陈洛南组生命科学与技术学院_特聘教授组_王鹏组生命科学与技术学院_硕士生
通讯作者	Wang, Guanyu; Wang, Peng; Chen, Luonan
作者单位	1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Syst Biol,Ctr Excellence Mol Cell Sci,Ins, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, Shanghai Inst Biol Sci, Biomed Big Data Ctr,Key Lab Computat Biol, Shanghai 200031, Peoples R China 3.East China Normal Univ, Inst Biomed Sci, Shanghai 200241, Peoples R China 4.East China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China 5.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 7.Southern Univ Sci & Technol, Dept Biol, Guangdong Prov Key Lab Computat Sci & Mat Design, Guangdong Prov Key Lab Cell Microenviroment & Dis, Shenzhen 518055, Peoples R China 8.Chinese Acad Sci, Shanghai Adv Res Inst, Lab Syst Biol, Shanghai 200031, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Jiang, Zhonglin,Lu, Lina,Liu, Yuwei,et al. SMAD7 and SERPINE1 as novel dynamic network biomarkers detect and regulate the tipping point of TGF-beta induced EMT[J]. SCIENCE BULLETIN,2020,65(10):842-853.
APA	Jiang, Zhonglin.,Lu, Lina.,Liu, Yuwei.,Zhang, Si.,Li, Shuxian.,...&Chen, Luonan.(2020).SMAD7 and SERPINE1 as novel dynamic network biomarkers detect and regulate the tipping point of TGF-beta induced EMT.SCIENCE BULLETIN,65(10),842-853.
MLA	Jiang, Zhonglin,et al."SMAD7 and SERPINE1 as novel dynamic network biomarkers detect and regulate the tipping point of TGF-beta induced EMT".SCIENCE BULLETIN 65.10(2020):842-853.