ShanghaiTech University Knowledge Management System
Body-Integrated, Enzyme-Triggered Degradable, Silk-Based Mechanical Sensors for Customized Health/Fitness Monitoring and In Situ Treatment | |
2020-07 | |
发表期刊 | ADVANCED SCIENCE (IF:14.3[JCR-2023],16.3[5-Year]) |
ISSN | none |
EISSN | 2198-3844 |
发表状态 | 已发表 |
DOI | 10.1002/advs.201903802 |
摘要 | Mechanical signals such as pressure and strain reflect important psychological and physiological states of the human body. Body-integrated sensors, including skin-mounted and surgically implanted ones, allow personalized health monitoring for the general population as well as patients. However, the development of such measuring devices has been hindered by the strict requirements for human-biocompatible materials and the need for high performance sensors; most existing devices or sensors do not meet all the desired specifications. Here, a set of flexible, stretchable, wearable, implantable, and degradable mechanical sensors is reported with excellent mechanical robustness and compliance, outstanding biocompatibility, remotely-triggered degradation, and excellent sensing performance, using a conductive silk fibroin hydrogel (CSFH). They can detect multiple mechanical signals such as pressure, strain, and bending angles. Moreover, combined with a drug-loaded silk-based microneedle array, sensor-equipped devices are shown to be effective for real-time monitoring and in situ treatment of epilepsy in a rodent model. These sensors offer potential applications in custom health monitoring wearables, and in situ treatment of chronic clinical disorders. |
关键词 | degradable sensors health monitoring in situ treatments mechanical sensors silk hydrogels |
收录类别 | SCI ; SCIE ; EI |
语种 | 英语 |
资助项目 | National Science and Technology Major Project from Minister of Science and Technology, China[2018AAA0103100][2020AAA0130100] ; National Natural Science Foundation of China[61574156][61904187] ; Scientific Instrument and Equipment Development Project of the Chinese Academy of Sciences[YJKYYQ20170060] ; National Science Fund for Excellent Young Scholars[61822406] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; Shanghai Outstanding Academic Leaders Plan[18XD1404700] ; Shanghai Sailing Program[19YF1456700] ; Youth Innovation Promotion Association CAS[2019236] |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
WOS记录号 | WOS:000531323300001 |
出版者 | WILEY |
WOS关键词 | PRESSURE ; HYDROGELS ; FORM |
原始文献类型 | Article |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120896 |
专题 | 物质科学与技术学院 物质科学与技术学院_特聘教授组_陶虎组 |
通讯作者 | Tao, Tiger H. |
作者单位 | 1.Chinese Acad Sci, State Key Lab Transducer Technol, Shanghai Inst Microsyst & Informat Technol, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Sch Grad Study, Beijing 100049, Peoples R China 3.Fudan Univ, Huashan Hosp, Dept Neurosurg, Shanghai 200040, Peoples R China 4.Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China 5.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 200031, Peoples R China 6.Inst Brain Intelligence Technol, Zhangjiang Lab, Shanghai 200031, Peoples R China 7.Shanghai Res Ctr Brain Sci & Brain Inspired Intel, Dept Brain Comp Interface, Shanghai, Peoples R China |
通讯作者单位 | 物质科学与技术学院 |
推荐引用方式 GB/T 7714 | Zhang, Shan,Zhou, Zhitao,Zhong, Junjie,et al. Body-Integrated, Enzyme-Triggered Degradable, Silk-Based Mechanical Sensors for Customized Health/Fitness Monitoring and In Situ Treatment[J]. ADVANCED SCIENCE,2020. |
APA | Zhang, Shan,Zhou, Zhitao,Zhong, Junjie,Shi, Zhifeng,Mao, Ying,&Tao, Tiger H..(2020).Body-Integrated, Enzyme-Triggered Degradable, Silk-Based Mechanical Sensors for Customized Health/Fitness Monitoring and In Situ Treatment.ADVANCED SCIENCE. |
MLA | Zhang, Shan,et al."Body-Integrated, Enzyme-Triggered Degradable, Silk-Based Mechanical Sensors for Customized Health/Fitness Monitoring and In Situ Treatment".ADVANCED SCIENCE (2020). |
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