Body-Integrated, Enzyme-Triggered Degradable, Silk-Based Mechanical Sensors for Customized Health/Fitness Monitoring and In Situ Treatment
2020-07
发表期刊ADVANCED SCIENCE (IF:14.3[JCR-2023],16.3[5-Year])
ISSNnone
EISSN2198-3844
发表状态已发表
DOI10.1002/advs.201903802
摘要

Mechanical signals such as pressure and strain reflect important psychological and physiological states of the human body. Body-integrated sensors, including skin-mounted and surgically implanted ones, allow personalized health monitoring for the general population as well as patients. However, the development of such measuring devices has been hindered by the strict requirements for human-biocompatible materials and the need for high performance sensors; most existing devices or sensors do not meet all the desired specifications. Here, a set of flexible, stretchable, wearable, implantable, and degradable mechanical sensors is reported with excellent mechanical robustness and compliance, outstanding biocompatibility, remotely-triggered degradation, and excellent sensing performance, using a conductive silk fibroin hydrogel (CSFH). They can detect multiple mechanical signals such as pressure, strain, and bending angles. Moreover, combined with a drug-loaded silk-based microneedle array, sensor-equipped devices are shown to be effective for real-time monitoring and in situ treatment of epilepsy in a rodent model. These sensors offer potential applications in custom health monitoring wearables, and in situ treatment of chronic clinical disorders.

关键词degradable sensors health monitoring in situ treatments mechanical sensors silk hydrogels
收录类别SCI ; SCIE ; EI
语种英语
资助项目National Science and Technology Major Project from Minister of Science and Technology, China[2018AAA0103100][2020AAA0130100] ; National Natural Science Foundation of China[61574156][61904187] ; Scientific Instrument and Equipment Development Project of the Chinese Academy of Sciences[YJKYYQ20170060] ; National Science Fund for Excellent Young Scholars[61822406] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; Shanghai Outstanding Academic Leaders Plan[18XD1404700] ; Shanghai Sailing Program[19YF1456700] ; Youth Innovation Promotion Association CAS[2019236]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号WOS:000531323300001
出版者WILEY
WOS关键词PRESSURE ; HYDROGELS ; FORM
原始文献类型Article
引用统计
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文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120896
专题物质科学与技术学院
物质科学与技术学院_特聘教授组_陶虎组
通讯作者Tao, Tiger H.
作者单位
1.Chinese Acad Sci, State Key Lab Transducer Technol, Shanghai Inst Microsyst & Informat Technol, Shanghai 200050, Peoples R China
2.Univ Chinese Acad Sci, Sch Grad Study, Beijing 100049, Peoples R China
3.Fudan Univ, Huashan Hosp, Dept Neurosurg, Shanghai 200040, Peoples R China
4.Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China
5.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 200031, Peoples R China
6.Inst Brain Intelligence Technol, Zhangjiang Lab, Shanghai 200031, Peoples R China
7.Shanghai Res Ctr Brain Sci & Brain Inspired Intel, Dept Brain Comp Interface, Shanghai, Peoples R China
通讯作者单位物质科学与技术学院
推荐引用方式
GB/T 7714
Zhang, Shan,Zhou, Zhitao,Zhong, Junjie,et al. Body-Integrated, Enzyme-Triggered Degradable, Silk-Based Mechanical Sensors for Customized Health/Fitness Monitoring and In Situ Treatment[J]. ADVANCED SCIENCE,2020.
APA Zhang, Shan,Zhou, Zhitao,Zhong, Junjie,Shi, Zhifeng,Mao, Ying,&Tao, Tiger H..(2020).Body-Integrated, Enzyme-Triggered Degradable, Silk-Based Mechanical Sensors for Customized Health/Fitness Monitoring and In Situ Treatment.ADVANCED SCIENCE.
MLA Zhang, Shan,et al."Body-Integrated, Enzyme-Triggered Degradable, Silk-Based Mechanical Sensors for Customized Health/Fitness Monitoring and In Situ Treatment".ADVANCED SCIENCE (2020).
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