Separation of twelve posaconazole related stereoisomers by multiple heart-cutting chiral-chiral two-dimensional liquid chromatography

doi:10.1016/j.chroma.2019.460845

	Separation of twelve posaconazole related stereoisomers by multiple heart-cutting chiral-chiral two-dimensional liquid chromatography
	Xu, Feng 1; Xu, Yao 1,2; Liu, Guizheng1,3 ; Zhang, Meng1,3 ; Qiang, Shangshang 1,2; Kang, Jingwu1,3
	2020-05-10
发表期刊	JOURNAL OF CHROMATOGRAPHY A (IF:3.8[JCR-2023],3.5[5-Year])
ISSN	0021-9673
EISSN	1873-3778
卷号	1618
发表状态	已发表
DOI	10.1016/j.chroma.2019.460845
摘要	Posaconazole represents a triazole antifungal agent which is used to treat various fungal infections. It contains four chiral centers leading to 16 stereoisomers. With the convergent synthesis route, only 11 related stereoisomeric impurities may potentially exist in the active pharmaceutical ingredient (API). It is a challenge to separate all the stereoisomers in one run. To address this problem, a multiple heart-cutting chiral-chiral two-dimensional liquid chromatography (2D-LC) method was developed. The multiple heart-cutting 2D-LC separation was implemented on 2D-LC system with three chiral columns with immobilized polysaccharide chiral stationary phases, namely Chiralpak IB, IC and IF3. In the system, the column Chiralpak IB was used as the D-1 separation column and IC and IF3 columns were used parallelly for the D-2 separation. The twelve stereoisomers were all well separated in one run by the multiple heart-cutting chiral-chiral 2D-LC system. (C) 2020 Elsevier B.V. All rights reserved.
关键词	Chiral drugs Multiple chiral centers Stereoisomers Two-dimensional liquid chromatography
收录类别	SCI ; SCIE ; EI
语种	英语
资助项目	National Natural Science Foundation of China[21775158][21375140][21175146] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB20020200]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemical Research Methods ; Chemistry, Analytical
WOS记录号	WOS:000528932300044
出版者	ELSEVIER
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120843
专题	物质科学与技术学院_博士生物质科学与技术学院_特聘教授组_康经武组物质科学与技术学院_硕士生
通讯作者	Kang, Jingwu
作者单位	1.Chinese Acad Sci, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem, State Key Lab Bioorgan Chem, 345 Lingling Lu, Shanghai 200032, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.ShanghaiTech Univ, Sch Phys Sci & Technol, Haike Rd 100, Shanghai 200120, Peoples R China
通讯作者单位	物质科学与技术学院
推荐引用方式 GB/T 7714	Xu, Feng,Xu, Yao,Liu, Guizheng,et al. Separation of twelve posaconazole related stereoisomers by multiple heart-cutting chiral-chiral two-dimensional liquid chromatography[J]. JOURNAL OF CHROMATOGRAPHY A,2020,1618.
APA	Xu, Feng,Xu, Yao,Liu, Guizheng,Zhang, Meng,Qiang, Shangshang,&Kang, Jingwu.(2020).Separation of twelve posaconazole related stereoisomers by multiple heart-cutting chiral-chiral two-dimensional liquid chromatography.JOURNAL OF CHROMATOGRAPHY A,1618.
MLA	Xu, Feng,et al."Separation of twelve posaconazole related stereoisomers by multiple heart-cutting chiral-chiral two-dimensional liquid chromatography".JOURNAL OF CHROMATOGRAPHY A 1618(2020).