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Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy | |
2009 | |
发表期刊 | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE |
ISSN | -- |
EISSN | 1582-4934 |
卷号 | 13期号:7页码:1358-1370 |
发表状态 | 已发表 |
DOI | 10.1111/j.1582-4934.2008.00360.x |
摘要 | The present study was designed to determine the effects of artemisinin (ARS) and its derivatives on human ovarian cancer cells, to evaluate their potential as novel chemotherapeutic agents used alone or in combination with a conventional cancer chemotherapeutic agent, and to investigate their underlying mechanisms of action. Human ovarian cancer cells (A2780 and OVCAR-3), and immortalized non-tumourigenic human ovarian surface epithelial cells (IOSE144), were exposed to four ARS compounds for cytotoxicity testing. The in vitro and in vivo antitumour effects and possible underlying mechanisms of action of dihydroartemisinin (DHA), the most effective compound, were further determined in ovarian cancer cells. ARS compounds exerted potent cytotoxicity to human ovarian carcinoma cells, with minimal effects on non-tumourigenic ovarian surface epithelial (OSE) cells. DHA inhibited ovarian cancer cell growth when administered alone or in combination with carboplatin, presumably through the death receptor- and, mitochondrion-mediated caspase-dependent apoptotic pathway. These effects were also observed in in vivo ovarian A2780 and OVCAR-3 xenograft tumour models. In conclusion, ARS derivatives, particularly DHA, exhibit significant anticancer activity against ovarian cancer cells in vitro and in vivo, with minimal toxicity to non-tumourigenic human OSE cells, indicating that they may be promising therapeutic agents for ovarian cancer, either used alone or in combination with conventional chemotherapy. |
关键词 | dihydroartemisinin artemisinin apoptosis ovarian cancer chemotherapy |
URL | 查看原文 |
语种 | 英语 |
WOS研究方向 | Cell Biology ; Research & Experimental Medicine |
WOS类目 | Cell Biology ; Medicine, Research & Experimental |
WOS记录号 | WOS:000268589200017 |
WOS关键词 | ENDOTHELIAL GROWTH-FACTOR ; HUMAN BREAST-CANCER ; IN-VITRO ; ARTEMISININ DERIVATIVES ; ANTIMALARIAL ARTESUNATE ; INHIBITS ANGIOGENESIS ; ANTITUMOR-ACTIVITY ; FACTOR EXPRESSION ; VIVO ; CHEMOTHERAPY |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120788 |
专题 | 个人在本单位外知识产出 |
通讯作者 | Wang, Hui |
作者单位 | 1.Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutr Sci, Shanghai Inst Biol Sci,Grad Sch, Shanghai 200031, Peoples R China 2.Univ Alabama, Div Clin Pharmacol, Dept Pharmacol & Toxicol, Birmingham, AL 35294 USA 3.Univ Alabama, Ctr Comprehens Canc, Birmingham, AL 35294 USA |
推荐引用方式 GB/T 7714 | Chen, Tao,Li, Mian,Zhang, Ruiwen,et al. Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2009,13(7):1358-1370. |
APA | Chen, Tao,Li, Mian,Zhang, Ruiwen,&Wang, Hui.(2009).Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,13(7),1358-1370. |
MLA | Chen, Tao,et al."Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 13.7(2009):1358-1370. |
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