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Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis | |
2009 | |
发表期刊 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA |
ISSN | 0027-8424 |
卷号 | 106期号:26页码:10728-10733 |
发表状态 | 已发表 |
DOI | 10.1073/pnas.0902707106 |
摘要 | Using Drosophila as a model system, we identified here a stringent requirement for Mre11-Rad50-Nbs (MRN) function in telomere protection during early embryonic development. Animals homozygous for hypomorphic mutations in either mre11 or nbs develop normally with minimal telomere dysfunction. However, they produce inviable embryos that succumb to failure of mitosis caused by covalent fusion of telomeric DNA. Interestingly, the molecular defect is not the absence of MRN interaction or of Mre11 nuclease activities, but the depletion of the maternal pool of Nbs protein in these embryos. Because of Nbs depletion, Mre11 and Rad50 (MR) are excluded from chromatin. This maternal effect lethality in Drosophila is similar to that seen in mice carrying hypomorphic mrn mutations found in human patients, suggesting a common defect in telomere maintenance because of the loss of MRN integrity. |
关键词 | maternal lethality telomere capping targeted mutagenesis ALTD |
URL | 查看原文 |
收录类别 | SCI |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000267564300062 |
WOS关键词 | DOUBLE-STRAND BREAK ; DNA-REPAIR ; MRE11/RAD50/NBS1 COMPLEX ; SACCHAROMYCES-CEREVISIAE ; BUDDING YEAST ; MRE11 COMPLEX ; MAINTENANCE ; CHECKPOINT ; PROTEIN ; ATM |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120397 |
专题 | 个人在本单位外知识产出 |
通讯作者 | Rong, Yikang S. |
作者单位 | NCI, Biochem & Mol Biol Lab, NIH, Bethesda, MD 20892 USA |
推荐引用方式 GB/T 7714 | Gao, Guanjun,Bi, Xiaolin,Chen, Jie,et al. Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2009,106(26):10728-10733. |
APA | Gao, Guanjun,Bi, Xiaolin,Chen, Jie,Srikanta, Deepa,&Rong, Yikang S..(2009).Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,106(26),10728-10733. |
MLA | Gao, Guanjun,et al."Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106.26(2009):10728-10733. |
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