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Highly Efficient Genome Modifications Mediated by CRISPR/Cas9 in Drosophila | |
Yu, Zhongsheng; Ren, Mengda; Wang, Zhanxiang; Zhang, Bo; Rong, Yikang S.; Jiao, Renjie; Gao, Guanjun | |
2013 | |
发表期刊 | GENETICS |
ISSN | 1943-2631 |
卷号 | 195期号:1页码:2890 |
发表状态 | 已发表 |
DOI | 10.1534/genetics.113.153825 |
摘要 | We report that Cas9/gRNA mediates efficient genetic modifications in Drosophila. Through targeting seven loci, we achieved a germline efficiency of up to 100%. Genes in both heterochromatin and euchromatin can be modified efficiently. Thus the Cas9/gRNA system is an attractive tool for rapid disruption of essentially any gene in Drosophila. |
URL | 查看原文 |
收录类别 | SCI |
WOS研究方向 | Genetics & Heredity |
WOS类目 | Genetics & Heredity |
WOS记录号 | WOS:000324174200024 |
WOS关键词 | GUIDED CAS9 NUCLEASE ; GENE ; MELANOGASTER ; TALEN |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120393 |
专题 | 个人在本单位外知识产出 |
共同第一作者 | Ren, Mengda |
通讯作者 | Jiao, Renjie; Gao, Guanjun |
作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China 3.Peking Univ, Coll Life Sci, Minist Educ, Key Lab Cell Proliferat & Differentiat, Beijing 100871, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100080, Peoples R China 5.NCI, Lab Biochem & Mol Biol, NIH, Bethesda, MD 20892 USA |
推荐引用方式 GB/T 7714 | Yu, Zhongsheng,Ren, Mengda,Wang, Zhanxiang,et al. Highly Efficient Genome Modifications Mediated by CRISPR/Cas9 in Drosophila[J]. GENETICS,2013,195(1):2890. |
APA | Yu, Zhongsheng.,Ren, Mengda.,Wang, Zhanxiang.,Zhang, Bo.,Rong, Yikang S..,...&Gao, Guanjun.(2013).Highly Efficient Genome Modifications Mediated by CRISPR/Cas9 in Drosophila.GENETICS,195(1),2890. |
MLA | Yu, Zhongsheng,et al."Highly Efficient Genome Modifications Mediated by CRISPR/Cas9 in Drosophila".GENETICS 195.1(2013):2890. |
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