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Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse | |
2007 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
卷号 | 317期号:5840页码:953-957 |
发表状态 | 已发表 |
DOI | 10.1126/science.1144233 |
摘要 | Carbon dioxide (CO2) is an important environmental cue for many organisms but is odorless to humans. It remains unclear whether the mammalian olfactory system can detect CO2 at concentrations around the average atmospheric level (0.038%). We demonstrated the expression of carbonic anhydrase type II (CAII), an enzyme that catabolizes CO2, in a subset of mouse olfactory neurons that express guanylyl cyclase D (GC-D+ neurons) and project axons to necklace glomeruli in the olfactory bulb. Exposure to CO2 activated these GC-D+ neurons, and exposure of a mouse to CO2 activated bulbar neurons associated with necklace glomeruli. Behavioral tests revealed CO2 detection thresholds of similar to 0.066%, and this sensitive CO2 detection required CAII activity. We conclude that mice detect CO2 at near-atmospheric concentrations through the olfactory subsystem of GC-D+ neurons. |
URL | 查看原文 |
收录类别 | SCI |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000248780200042 |
WOS关键词 | CARBON-DIOXIDE DETECTION ; GATED CATION CHANNEL ; SENSORY NEURONS ; DETECTION THRESHOLD ; ANHYDRASE ; MICE ; STIMULATION ; DROSOPHILA ; DEFICIENT ; ANOSMIA |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120348 |
专题 | 个人在本单位外知识产出 |
共同第一作者 | Zhong, Chun |
通讯作者 | Luo, Minmin |
作者单位 | 1.Natl Inst Biol Sci, Beijing 102206, Peoples R China 2.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China 3.Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA 4.Rockefeller Univ, New York, NY 10021 USA |
推荐引用方式 GB/T 7714 | Hu, Ji,Zhong, Chun,Ding, Cheng,et al. Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse[J]. SCIENCE,2007,317(5840):953-957. |
APA | Hu, Ji.,Zhong, Chun.,Ding, Cheng.,Chi, Qiuyi.,Walz, Andreas.,...&Luo, Minmin.(2007).Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse.SCIENCE,317(5840),953-957. |
MLA | Hu, Ji,et al."Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse".SCIENCE 317.5840(2007):953-957. |
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