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Dec2 Promotes Th2 Cell Differentiation by Enhancing IL-2R Signaling | |
2009 | |
发表期刊 | JOURNAL OF IMMUNOLOGY |
ISSN | 0022-1767 |
EISSN | 1550-6606 |
卷号 | 183期号:10页码:6320-6329 |
发表状态 | 已发表 |
DOI | 10.4049/jimmunol.0900975 |
摘要 | Th cell differentiation is precisely regulated by thousands of genes at different stages. In the present study, we demonstrate that Dec2, a transcription factor belonging to the bHLH (basic helix-loop-helix) superfamily, is progressively induced during the course of Th2 differentiation, especially at the late stage. The up-regulated Dec2 can strongly promote Th2 development under Th2-inducing conditions, as evidenced by retrovirus-mediated gene transfer or transgenic manipulation. In addition, an enhancement of Th2 responses is also detectable in Dec2 transgenic mice in vivo. Conversely, RNA interference-mediated suppression of endogenous Dec2 could attenuate Th2 differentiation. Finally, we show that the enhanced Th2 development is at least in part due to substantial up-regulation of CD25 expression elicited by Dec2, thereby resulting in hyperresponsiveness to IL-2 stimulation. The Journal of Immunology, 2009, 183: 6320-6329. |
URL | 查看原文 |
收录类别 | SCI |
WOS研究方向 | Immunology |
WOS类目 | Immunology |
WOS记录号 | WOS:000271765700034 |
WOS关键词 | CD4 T-CELLS ; GENE-EXPRESSION ; TRANSCRIPTION FACTORS ; ACTIVATION ; MECHANISMS ; REPRESSION ; INDUCTION ; RESPONSES ; ELEMENTS ; HYPOXIA |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120218 |
专题 | 个人在本单位外知识产出 |
通讯作者 | Xiang, Charlie; Sun, Bing |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Mol Cell Biol Lab, Inst Biochem & Cell Biol, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Pasteur Shanghai, Shanghai, Peoples R China 3.Fudan Univ, Sch Med, Shanghai 200433, Peoples R China 4.Zhejiang Univ, Sch Med, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Hangzhou 310003, Zhejiang, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, Zhiduo,Li, Zhenhu,Mao, Kairui,et al. Dec2 Promotes Th2 Cell Differentiation by Enhancing IL-2R Signaling[J]. JOURNAL OF IMMUNOLOGY,2009,183(10):6320-6329. |
APA | Liu, Zhiduo.,Li, Zhenhu.,Mao, Kairui.,Zou, Jia.,Wang, Yuan.,...&Sun, Bing.(2009).Dec2 Promotes Th2 Cell Differentiation by Enhancing IL-2R Signaling.JOURNAL OF IMMUNOLOGY,183(10),6320-6329. |
MLA | Liu, Zhiduo,et al."Dec2 Promotes Th2 Cell Differentiation by Enhancing IL-2R Signaling".JOURNAL OF IMMUNOLOGY 183.10(2009):6320-6329. |
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