Structure and mechanism of bacterial tripartite efflux pumps

doi:10.1016/j.resmic.2018.05.003

	Structure and mechanism of bacterial tripartite efflux pumps
	Neuberger, Arthur; Du, Dijun; Luisi, Ben E.
	2018
发表期刊	RESEARCH IN MICROBIOLOGY (IF:2.5[JCR-2023],3.3[5-Year])
ISSN	0923-2508
EISSN	1769-7123
卷号	169 期号:2020-07-08 页码:401-413
发表状态	已发表
DOI	10.1016/j.resmic.2018.05.003
摘要	Efflux pumps are membrane proteins which contribute to multi-drug resistance. In Gram-negative bacteria, some of these pumps form complex tripartite assemblies in association with an outer membrane channel and a periplasmic membrane fusion protein. These tripartite machineries span both membranes and the periplasmic space, and they extrude from the bacterium chemically diverse toxic substrates. In this chapter, we summarise current understanding of the structural architecture, functionality, and regulation of tripartite multi-drug efflux assemblies. (C) 2018 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
关键词	Multi-drug efflux pumps Membrane proteins Antibiotic resistance Tripartite assemblies
收录类别	SCI
语种	英语
WOS研究方向	Microbiology
WOS类目	Microbiology
WOS记录号	WOS:000447154200008
WOS关键词	GRAM-NEGATIVE BACTERIA ; ENTERICA SEROVAR TYPHIMURIUM ; ESCHERICHIA-COLI HEMOLYSIN ; TYPE-1 SECRETION SYSTEM ; MEMBRANE-FUSION PROTEIN ; 2-COMPONENT SIGNAL-TRANSDUCTION ; MULTIPLE ANTIBIOTIC-RESISTANCE ; TRANSPORTER P-GLYCOPROTEIN ; MULTIDRUG ABC TRANSPORTER ; DRUG-BINDING POCKET
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120170
专题	个人在本单位外知识产出
通讯作者	Luisi, Ben E.
作者单位	Univ Cambridge, Dept Biochem, Tennis Court Rd, Cambridge CB2 1GA, England
推荐引用方式 GB/T 7714	Neuberger, Arthur,Du, Dijun,Luisi, Ben E.. Structure and mechanism of bacterial tripartite efflux pumps[J]. RESEARCH IN MICROBIOLOGY,2018,169(2020-07-08):401-413.
APA	Neuberger, Arthur,Du, Dijun,&Luisi, Ben E..(2018).Structure and mechanism of bacterial tripartite efflux pumps.RESEARCH IN MICROBIOLOGY,169(2020-07-08),401-413.
MLA	Neuberger, Arthur,et al."Structure and mechanism of bacterial tripartite efflux pumps".RESEARCH IN MICROBIOLOGY 169.2020-07-08(2018):401-413.